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EC number: 947-057-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 - 29 September 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- GLP Study conducted according to OECD Guideline 401 with deviations: purity of test substance not reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- yes
- Remarks:
- purity of test substance not reported
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-hydroxy-3-[(1-oxodocosyl)oxy]propyltrimethylammonium chloride
- EC Number:
- 274-033-6
- EC Name:
- 2-hydroxy-3-[(1-oxodocosyl)oxy]propyltrimethylammonium chloride
- Cas Number:
- 69537-38-8
- Molecular formula:
- C28H58NO3.Cl
- IUPAC Name:
- 3-(docosanoyloxy)-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Reference substance name:
- 2-methylpentane-2,4-diol
- EC Number:
- 203-489-0
- EC Name:
- 2-methylpentane-2,4-diol
- Cas Number:
- 107-41-5
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 2-methylpentane-2,4-diol
- Test material form:
- solid
- Remarks:
- paste opac
- Details on test material:
- - Physical state: Paste opac
- Storage condition of test material: At room temperature in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sulzfeld, FRG.
- Age at study initiation: 8 weeks
- Weight at study initiation: 251 ± 6.4 g (males); 196 ± 10.5 g (females)
- Fasting period before study: Animals were fasted overnight prior to dosing until 3-4 hours after administration of the test substance.
- Housing: Animals were individually housed in polycarbonate cages containing purified sawdust as bedding material.
- Diet: Standard pelleted laboratory animal diet (RMH-B, Hope Farms, Woerden, The Netherlands), ad libitum
- Water: Tap-water (via automatic nozzles), ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-22 °C
- Humidity: 60-90 %
- Photoperiod: 12 h dark / 12 h light
IN-LIFE DATES: 15 - 29 September 1987
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- reverse osmosis wate
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg bw
DOSAGE PREPARATION: The test substance was suspended in reverse osmosis water and administered once only by gavage using a stainless steel stomach cannula attached to a disposable plastic syringe. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Cage-side observations were performed on the day of dosing (approximately once every two hours) and once daily thereafter for 14 days. Individual body weights were measured weekly.
- Necropsy of survivors performed: Yes; at the end of the study (day 14) all animals were killed by CO2-asphyxiation and subjected to necropsy. - Statistics:
- None
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- No signs of systemic toxicity were observed during the 14-day observation period.
- Body weight:
- All animals showed body weight gain during the study period.
- Gross pathology:
- Macroscopic examination of all animals at the end of the study revealed no gross abnormalities.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the oral LD50 of the test substance is higher than 2000 mg/kg bw in rats therefore it is not classified for acute oral toxicity according to the criteria of the Annex VI of the Regulation EC No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In an acute oral toxicity study performed according to OECD Guideline No. 401 and in compliance with GLP, groups (5/sex/dose) of Wistar rats were given a single oral (gavage) dose of test substance at 2000 mg/kg bw. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and at the end of the study the surviving animals were sacrificed for macroscopic examination.
No mortalities occurred and no signs of systemic toxicity were observed during the 14-day observation period. All animals showed body weight gain during the study period. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
Oral LD50 Combined > 2000 mg/kg bw.
Under the test conditions, the test substance is not classified for acute oral toxicity according to the criteria of the Annex VI of the Regulation EC No. 1272/2008 (CLP) and to the GHS.
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