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EC number: 212-214-3 | CAS number: 769-78-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
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- Toxicological Summary
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- Irritation / corrosion
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![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 - 25 Sep 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 24 Apr 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- Commission Directive No. 2004/73/EC
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
Test material
- Reference substance name:
- Vinyl benzoate
- EC Number:
- 212-214-3
- EC Name:
- Vinyl benzoate
- Cas Number:
- 769-78-8
- Molecular formula:
- C9H8O2
- IUPAC Name:
- vinyl benzoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Limited, Bicester, UK
- Age at study initiation: 12 - 20 weeks
- Weight at study initiation: 2.0 - 3.5 kg
- Housing: individually in suspended cages
- Diet: certified rabbit diet, ad libitum
- Water: drinking water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eye remained untreated and served as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- SCORING SYSTEM: Draize scoring system; reading time points: 1, 24, 48 and 72 h
TOOL USED TO ASSESS SCORE: ophthalmoscope
OTHER OBSERVATIONS:
Body weight was measured on Day 0 and 3.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 h (animal #1)
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- No corneal opacity was noted during the study. Iridial inflammation was noted in one treated eye one hour after treatment. Moderate conjunctival irritation was noted in all treated eyes one hour after treatment with minimal conjunctival redness at the 24-hour observation. Minimal conjunctival redness persisted in one treated eye at the 48-hour observation. Two treated eyes appeared normal at the 48-hour observation and the remaining treated eye appeared normal at the 72-hour observation. Minimal conjunctival chemosis was observed 1 hour after instillation and was reversible within 24 hours.
- Other effects:
- - Other observations: All animals showed expected gain in bodyweight during the study.
Any other information on results incl. tables
Table 1. Results of eye irritation/corrosion study in rabbits.
Alteration |
Animal No. |
Time (h) |
|||||
1 |
24 |
48 |
72 |
mean 24/48/72 h |
reversible within |
||
Cornea |
1 |
0 |
0 |
0 |
0 |
0 |
n.a. |
2 |
0 |
0 |
0 |
0 |
0 |
n.a. |
|
3 |
0 |
0 |
0 |
0 |
0 |
n.a. |
|
Iris |
1 |
1 |
0 |
0 |
0 |
0 |
24 h |
2 |
0 |
0 |
0 |
0 |
0 |
n.a. |
|
3 |
0 |
0 |
0 |
0 |
0 |
n.a. |
|
Conjunctivae Redness |
1 |
2 |
1 |
0 |
0 |
0.33 |
48 h |
2 |
2 |
1 |
0 |
0 |
0.33 |
48 h |
|
3 |
2 |
1 |
1 |
0 |
0.67 |
72 h |
|
Conjunctivae Chemosis |
1 |
1 |
0 |
0 |
0 |
0 |
24 h |
2 |
1 |
0 |
0 |
0 |
0 |
24 h |
|
3 |
1 |
0 |
0 |
0 |
0 |
24 h |
n.a. : not applicable
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to CLP Regulation (EC) No 1272/2008
- Conclusions:
- Vinyl benzoate was tested for eye irritation in 3 rabbits according to the OECD TG 405. With respect to the findings reported at reading time points 24, 48 and 72 h for the 3 animals, the resulting mean Draize scores for corneal opacity and iritis were < 1 and for conjunctival redness and oedema < 2, respectively; thus no classification according the CLP Regulation is warranted and the compound is considered not to be an eye irritant according to the CLP criteria.
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