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EC number: 695-022-6 | CAS number: 473278-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Stability in water:
The test substance was shown to be hydrolytically stable at pH 4, 7, and 9 [t1/2 (25°C) > 1 year].
Phototransformation on soil is likely to contribute to the degradation of the test substance under outdoor conditions, based on the experimental DT50 value of 3.9 days for irradiated samples, from which 10.4 and 16.1 solar summer days at Phoenix (Arizona, USA) and Athens (Greece) are calculated, respectively
Biodegradability:
Not ready biodegradable
Aerobic Biodegradation in soil (DT50): 5.9 – 60.9 days at 12°C (temperature corrected values)
Anaerobic Biodegradation in soil (DT50): > 1000 days at 20 °C
Adsorption/desorption:
Koc values are in the range of 33.7 to 246.7 mL/g. Depending on the soil type the mobility of the test substance can be classified from mobile to low mobile in the tested soils.
Additional information
Stability:
In a first approach, data on the potential for hydrolysis are indicative for the stability of the test item in the environment. Following “Notification Concerning Test Data for Registration of Agricultural Chemicals” (12 Nohsan No. 8147) and the measurement method stipulated in the OECD Test Guideline 111 the abiotic hydrolysis of 2-{2-chloro-4-mesyl-3-[(tetrahydrofuran-2-lmethoxy)methyl]benzoyl}cyclohexane-1,3-dione was tested in a GLP study. The study was performed at pH 4, 7 and 9 (M-398574-01-2; 2004) at 50 °C in aqueous solution. Under the conditions of the test the substance was shown to be hydrolytically stable [t1/2 (25°C) > 1 year].
Phototransformation on soil is likely to contribute to the degradation of the test substance under outdoor conditions. Based on the experimental DT50 value of 3.9 days for irradiated samples, the half-life of the test substance under environmental conditions is calculated to be e.g. 10.4 solar summer days at Phoenix (Arizona, USA) or 16.1 solar summer days at Athens (Greece).
Biodegradation:
The substance is considered to be not readily biodegradable. However, the results of biodegradation studies in soil indicate that the substance is not expected to have a potential for accumulation in the environment under aerobic conditions. The calculated half-lives ranged between 2.7 and 18.3 days under the chosen test conditions, which correspond to temperature corrected DT50 values of 5.9 – 60.9 at 12°C (average environmental temperature in Europe).
Adsorption/desorption:
A study conducted under GLP and according to OECD guideline 106 and US EPA OPPTS 835.1220 is available (M-442744-01-1; 2012 and M-442744-02-1; 2014). Five different soils were used in this study.
The following table summarizes the key soil properties and results:
Soil origin |
#1 |
#2 |
#3 |
#4 |
#5 |
Soil type (USDA) |
Sandy loam |
Silt loam |
Loam |
Loamy sand |
Silt loam |
pH (0.01MCaCl2) |
5.1 |
6.3 |
7.3 |
5.9 |
5.2 |
Organic carbon [%] |
2.0 |
2.9 |
4.4 |
2.0 |
2.9 |
KF(ads)[mL/g] |
4.9 |
1.9 |
1.5 |
1.8 |
5.1 |
1/n |
0.8740 |
0.8700 |
0.8515 |
0.8678 |
0.8681 |
KF,OC(ads)[mL/g] |
246.7 |
66.4 |
33.7 |
63.5 |
175.0 |
Mean KF,OC(ads): 117 mL/g
Depending on the soil type the mobility of 2-{2-chloro-4-mesyl-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione
can thus be classified as mobile or of low mobility.
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