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Diss Factsheets
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EC number: 916-331-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: short-term (with study design considered suitable for long-term assessment)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2017 - February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
- Version / remarks:
- July 19, 2006
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Verdox Cas no 20298-69-5
- IUPAC Name:
- Verdox Cas no 20298-69-5
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Verdox
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- Test substance has been confirmed in the stock solution
- Details on sampling:
- Duplicat specimen of the homogenous stock solutions and the two spicemen of the matrix (acetone) as control were taken.
Test substrate
- Vehicle:
- yes
- Remarks:
- Aceton
- Details on preparation and application of test substrate:
- The test substance was dissolved in aceton and mixed with fine quartz sand before the test substance treated sand was mixed into the soil
Test organisms
open allclose all
- Species:
- Allium cepa
- Plant group:
- Monocotyledonae (monocots)
- Species:
- Avena sativa
- Plant group:
- Monocotyledonae (monocots)
- Species:
- Cucumis sativus
- Plant group:
- Dicotyledonae (dicots)
- Species:
- other: Solanum lycopersicum
- Plant group:
- Dicotyledonae (dicots)
- Species:
- Glycine max (G. soja)
- Plant group:
- Dicotyledonae (dicots)
- Species:
- Brassica napus
- Plant group:
- Dicotyledonae (dicots)
Study design
- Test type:
- seedling emergence and seedling growth test
- Study type:
- laboratory study
- Substrate type:
- natural soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Remarks:
- Fourteen to 21 days after 50% germination of the control
- Post exposure observation period:
- No
Test conditions
- Test temperature:
- 21
- pH:
- 5.9
- Moisture:
- 65
- Nominal and measured concentrations:
- Nominal concentration were used
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Species:
- other: Plant average
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 44 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks on result:
- other: EC10 average
- Remarks:
- Number of species >=5
- Key result
- Species:
- Brassica napus
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 48.2 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Key result
- Species:
- Glycine max (G. soja)
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 33.2 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Key result
- Species:
- other: Solanum lycopersicum
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 17.2 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Key result
- Species:
- Cucumis sativus
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 92 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Key result
- Species:
- Avena sativa
- Duration:
- 14 d
- Dose descriptor:
- EC10
- Effect conc.:
- 67.7 mg/kg soil dw
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Key result
- Species:
- Allium cepa
- Duration:
- 21 d
- Dose descriptor:
- EC10
- Effect conc.:
- 10.9 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Reported statistics and error estimates:
- Statistical analysis of the control plants and solvent control plants:
Update for Verdox
Fresh weight data were tested for normal distribution and homogeneity of variance (F test, = 0.05). If the data were normally distributed and homogeneous the Student t-test (pairwise comparison, two-sided, = 0.05) was used. If the data were not normally distributed the Mann-Whitney U-test (pairwise comparison, two-sided, = 0.05) was used.
Any other information on results incl. tables
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Germination Rate of the Control Seeds wat at least 70%; Mean Survival of Emerged Control Seedlings was > 90%; the control seedlings did not exhibit phytotoxic effects.
- Conclusions:
- The EC10 of 44 mg/kg soil dw will be used for the CSA, which is an average EC10 over 6 plant species.
- Executive summary:
In a terrestrial plant test according to OECD TG 208 under GLP, 6 plant species were tested for seedling emergence, growth and phytotoxic effects (chlorosis, necrosis and abnormal growth). The soil is a sandy loam and was sterilised before use. All particles were < 0.2cm. The organic matter content is 0.67 +/-0.03% and the pH was 5.9 +/-0.6. The substance was mixed with quarts sand and thereafter mixed into the soil. The following dicotyles were used: Brassica napus, Glycine max, Solanum lycopersicum and Cucumis sativus. The following monocotyles were use: Avena sativa and Allium cepa. Doses were selected based on a dose range finding study and were 12.3, 37, 111, 333 and 1000 mg/kg soil dw for most species. Two additional concentrations were used for Brassica napus and Glycine max: 1.37 and 4.12 mg/kg dw soil. One additional concentration was used for Solanum lycopersicum: 4.12 mg/kg dw soil. The concentration in the stock solution was verified but actual measures in the soil were not performed. Untreated seeds were sewn in pots and plants were grown for 14 days, except Allium cepa which was grown for 21 days. Fresh weight of the leaves of plants was the more sensitive endpoint compared to germination, phytotoxicity and mortality. The EC10 of all six plant species was averaged as the number of species =>5. The overall EC10 on leaf fresh weight being the most sensitive parameter resulted in 44 mg/kg soil dw based on nominal values and being the average of 6 plant species based on nominal values.
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