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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits
Author:
Flickinger C.W.
Year:
1976
Bibliographic source:
American Industrial Hygiene Association Journal, Volume 37, October 1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: US FHSA, US Federal Register of Aug 12, 1961, pp 7333-7341, Part 191
Principles of method if other than guideline:
24h exposure to 0.5g moistend with water, scoring at 24h and 72h, on intact and abraded rabbit skin
GLP compliance:
no

Test material

Constituent 1
Test material form:
solid: flakes
Details on test material:
supplier: Koppers Company, Inc.
Name: Resorcinol

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No details provided
Male albino rabbits

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded
Vehicle:
physiological saline
Controls:
not specified
Amount / concentration applied:
0.5g
Duration of treatment / exposure:
24h
Observation period:
14 days.
Number of animals:
6
Details on study design:
treated are were the bellies
Skin was either intact or abraded.
Scoring was done after 24h and after 72h

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Time point:
72 h
Score:
1.5
Max. score:
4
Remarks on result:
other: value for intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
1.3
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: value for intact skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
1.2
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: value for intact skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
0.7
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: value for intact skin
Irritant / corrosive response data:
Based on the PII, the substance is described by the authors as "not a primary irritant".
Other effects:
For sites of intact skin, treatment resulted in no perceptible to moderate findings.
If abraded skin was treated, the sites showed results ranging from not perceptible to necrosis. At the end of the 14-day period, the necrotic sites were either still incrusted or scarred. The other sites had healed and areas were free of signs of irritiation.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met