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Diss Factsheets
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EC number: 218-427-8 | CAS number: 2150-46-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits
- Author:
- Flickinger C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, Volume 37, October 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US FHSA, US Federal Register of Aug 12, 1961, pp 7333-7341, Part 191
- Principles of method if other than guideline:
- 24h exposure to 0.5g moistend with water, scoring at 24h and 72h, on intact and abraded rabbit skin
- GLP compliance:
- no
Test material
- Test material form:
- solid: flakes
- Details on test material:
- supplier: Koppers Company, Inc.
Name: Resorcinol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No details provided
Male albino rabbits
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 24h
- Observation period:
- 14 days.
- Number of animals:
- 6
- Details on study design:
- treated are were the bellies
Skin was either intact or abraded.
Scoring was done after 24h and after 72h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Time point:
- 72 h
- Score:
- 1.5
- Max. score:
- 4
- Remarks on result:
- other: value for intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: value for intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: value for intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: value for intact skin
- Irritant / corrosive response data:
- Based on the PII, the substance is described by the authors as "not a primary irritant".
- Other effects:
- For sites of intact skin, treatment resulted in no perceptible to moderate findings.
If abraded skin was treated, the sites showed results ranging from not perceptible to necrosis. At the end of the 14-day period, the necrotic sites were either still incrusted or scarred. The other sites had healed and areas were free of signs of irritiation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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