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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
other: acute oral toxicity study
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzothiazol-2-yl sulphide
EC Number:
219-660-8
EC Name:
Sodium benzothiazol-2-yl sulphide
Cas Number:
2492-26-4
Molecular formula:
C7H4NS2.Na
IUPAC Name:
sodium 2-sulfanylidene-2,3-dihydro-1,3-benzothiazol-3-ide
Details on test material:
Merkaptobenzthiazol-Na (50% solution)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
male Wistar rats, SPF, weight 10- to 180 g, husbandry 5 animals per cage

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no further data
Doses:
0.5, 1.0, 2.0, 3.1, 3.5, 4.0, 5.0 ml /kg; (about 400, 800, 1600, 2480, 2800, 3200, 4000 mg/kg
densitiy ~ 1.25 g/cm³ (ECB IUCLID 2000)
No. of animals per sex per dose:
10 per dose
Control animals:
no
Details on study design:
no further data
Statistics:
LD50 according Fink und Hund, Arzneim.-Forsch 15, 624 (1965)

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 100 mg/kg bw
Based on:
test mat.
Remarks on result:
other: clinical signs
Mortality:
dose 0.5 ml/kg, mortality 0/10; dose 1.0 ml/kg, mortality 1/10 rats; dose 2.0 ml/kg, mortality 2/10; dose 3.1 ml/kg, mortality 4/10; dose 3.5 ml/kg, mortality 8/10; dose 4.0 ml; mortality 8/10; dose 5.0 ml/kg, mortality 10/10
Clinical signs:
other: sedation, breathing disturbance, myoclonus
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

Mortality occurred 3 min to 2 d after test substance application

Clinical signs observed: sedation, difficulties in respiration, myoclonus

 Dosis ml/kg  Calculated dosis in mg/kg (densitiy ~ 1.25 g/cm³)  Clinical signs  Mortality  Time of death
 0.5  400  0/10  0/10  -
 1.0  800  10/10  1/10  3 h
 2.0  1600  10/10  2/10  3 h
 3.1  2480  10/10  4/10 3 h 
 3.5  2800  10/10 8/10   2d
 4.0  3200  10/10  8/10  3 h
 5.0  4000  10/10  10/10  30 min

Applicant's summary and conclusion

Executive summary:

method: 10 male rats each received a single orale application per gavage of 0.5, 1.0, 2.0, 3.1, 3.5, 4.0, 5.0 ml test substance/kg bw, post-observation time 14 days

result: LD50 (male rats) = 2.63 ml/kg bw (~ 2100 mg/kg bw), clinical signs: sedation, breathing disturbance, myoclonus

reference: Loeser/Bayer AG (1978)