Registration Dossier
Registration Dossier
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EC number: 200-340-1 | CAS number: 57-57-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- grey literature
- Title:
- NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards
- Author:
- Mackinson et al.
- Year:
- 1 981
- Bibliographic source:
- DHHS(NIOSH) Publication no. 81-13 (3. VOLS) Washington DC: US Government Printing Office, Jan. 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propiolactone
- EC Number:
- 200-340-1
- EC Name:
- Propiolactone
- Cas Number:
- 57-57-8
- Molecular formula:
- C3H4O2
- IUPAC Name:
- oxetan-2-one
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Permanent corneal opacification
- Reversibility:
- not reversible
- Remarks on result:
- other: Eye contact with liquid beta-propiolactone can cause permanent corneal opacification
- Irritant / corrosive response data:
- Eye contact with liquid beta-propiolactone can cause permanent corneal opacification
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
