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EC number: 202-462-0 | CAS number: 95-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 4-Chlororesorcinol is found to be irritating to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from review article.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g (0.5 g, moistened with 60 ml Milli-U water)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours, and 7 and 14 days after exposure.
- Number of animals:
- 3 male rabbit
- Details on study design:
- TEST SITE
- Area of exposure: Clipped skin
- Type of wrap if used: semi-occlusive dressing
SCORING SYSTEM: erythema, oedema, full thickness destruction of the skin or scar tissue - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1-14 days
- Reversibility:
- no data
- Remarks on result:
- other: Slight, well defined or moderate to severe erythema and slight or moderate oedema
- Irritant / corrosive response data:
- Four hours exposure to 0.5 g of4-Chlororesorcinol resulted in slight, well defined or moderate to severe erythema and slight or moderate
oedema in the treated skin-areas of the three rabbits. The skin irritation had resolved within 14 days after exposure in one animal, but remained present up to termination in the other animals. - Other effects:
- No evidence of full thickness destruction of the skin or scar tissue was observed during the observation period, indicating that no corrosion of the
skin had occurred by dermal application of A12 to the intact rabbit skin. Brown staining of the treated skin by the test substance was observed on all animals during the observation period, which did not hamper
the scoring of the skin reaction - Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4-Chlororesorcinol is found to be irritating to the skin of rabbit when treated at 0.5g of concentration for 4 hrs.
- Executive summary:
A skin irritation study for 4-Chlororesorcinol was observed on New Zealand White strain rabbit. No evidence of full thickness destruction of the skin or scar tissue was observed during the observation period, indicating that no corrosion of the skin had occurred by dermal application of 4-Chlororesorcinol to the intact rabbit skin.
Brown staining of the treated skin by the test substance was observed on all animals during the observation period, which did not hamper the scoring of the skin reaction.
Four hours exposure to 0.5 g of 4-Chlororesorcinol resulted in very slight, well defined or moderate to severe erythema and slight or moderate oedema in the treated skin-areas of the three rabbits. The skin irritation had resolved within 14 days after exposure in one animal, but remained present up to termination in the other animals.
Thus from overall observation of the study it can be concluded that 4-Chlororesorcinol is likely to be irritating to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from review article.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Sex: male
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 56.1 mg neat test substance (a volume of approximately 0.1 ml)
- Observation period (in vivo):
- 1 and 24 hours
- Number of animals or in vitro replicates:
- 1 male rabbit
- Details on study design:
- TEST SITE
- Area of exposure: Corneal area
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM: Corneal and conjunctival parameters - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: corneal injury consisted of opacity (maximum grade 4) and epithelial damage (100% of the corneal area).
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: The irritation of the conjunctivae consisted of redness (also of the outside of the eyelids), chemosis and discharge.
- Irritant / corrosive response data:
- In addition, grey-white discolouration (a sign of necrosis) of the eyelids and nictitating membrane was noted during the observation period.
Due to the corneal damage, iridial irritation could not be assessed. - Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4-Chlororesorcinol is found to be irritating to New Zealand White strain rabbit eye when treated at 56.1 mg neat concentration.
- Executive summary:
Eye irritation study for 4-Chlororesorcinol was observed on New Zealand White strain rabbit. A single sample of 56.1 mg of 4-Chlororesorcinol (a volume of approximately 0.1 ml) was instilled into an eye of one rabbit.
Observations were made 1 and 24 hours after instillation. The corneal injury consisted of opacity (maximum grade 4) and epithelial damage (100% of the corneal area).
The irritation of the conjunctivae consisted of redness (also of the outside of the eyelids), chemosis and discharge. In addition, grey-white discoloration (a sign of necrosis) of the eyelids and nictitating membrane was noted during the observation period. Due to the corneal damage, iridial irritation could not be assessed. Based on the severity of the eye lesions, the animal was sacrificed for ethical reasons after the 24 hours observation.
Therefore, it can be concluded that 4-Chlororesorcinol is likely to be irritating to New Zealand White strain rabbit eye.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
Weight of evidence studies were reviewed for skin irritation from reliable sources having Klimish rating 2 and 4.
The summary of the results are presented below:
Sr.No |
Irritation Parameter |
Species |
Interpretation of results |
Conclusions |
Sources |
1 |
Overall irritation score |
Rabbit |
Irritating |
4-Chlororesorcinol is found to be irritating to the skin of rabbit when treated at 0.5g of concentration for 4 hrs. |
Data from Scientific Committee on Consumer Safety (SCCS) - report |
2 |
Primary dermal irritation index (PDII) |
Rabbit |
Not irritating |
4-Chlororesorcinol is found to be non –irritant on New Zealand White strain rabbit skin when tested 2.5 % (w/v) concentration for 72 h. |
Data from Publication |
3 | Primary dermal irritation index | Rabbit | moderatly irritating | 4-chlororesorcinol, it was estimated that the dermal irritation index is 3.6 tested on rabbits. Based on this value, it can be concluded that 4-chlororesorcinol is mooderatly irritating to skin. | Predicted data |
Based on the weight of evidence available, it is concluded that the substance 4-Chlororesorcinol is likely to be irritating to the skin
of rabbit and thus can be classified as skin irri 2 category as per the criteria of CLP regulation.
Eye irritation
The summary of the results are presented below:
Sr.No |
Irritation Parameter |
Species |
Interpretation of results |
Conclusions |
Sources |
1 |
Corneal and Conjunctivae score |
Rabbit |
Irritating |
4-Chlororesorcinol is found to be irritating to New Zealand White strain rabbit eye. |
Data from Scientific Committee on Consumer Safety (SCCS) - report |
Based on the above data, it is concluded that the substance 4-Chlororesorcinol is likely to be irritating to th
eye of rabbit.Justification for selection of skin irritation / corrosion endpoint:
4-Chlororesorcinol is found to be irritating to the skin of rabbit when treated at 0.5g of concentration for 4 hrs.
Justification for selection of eye irritation endpoint:
4-Chlororesorcinol is found to be irritating to New Zealand White strain rabbit eye when treated at 56.1 mg neat concentration.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
The available data indicates that the substance 4-Chlororesorcinol is likely to classify as a skin and eye irritant according to criteria of the CLP regulation.
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