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EC number: 249-984-5 | CAS number: 29976-53-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 September 2016 - 22 December 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- Ethyl 4-oxopiperidine-1-carboxylate
- EC Number:
- 249-984-5
- EC Name:
- Ethyl 4-oxopiperidine-1-carboxylate
- Cas Number:
- 29976-53-2
- Molecular formula:
- C8H13NO3
- IUPAC Name:
- ethyl 4-oxopiperidine-1-carboxylate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-126971-AAA (T000509)
- Physical state: liquid
- Appearance: clear colourless to light yellow liquid
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: M15HB3826
- Expiration date: 13 January 2017
- Analytical purity: 98.5% (based on GC purity)
- Storage condition of test material: At room temperature
Results and discussion
Boiling point
- Key result
- Boiling pt.:
- 274.4 °C
- Atm. press.:
- ca. 1 022 hPa
Any other information on results incl. tables
During Experiment 2, an endothermic peak between 150°C and 300°C was observed. The effect was most likely obtained due to boiling of the test item. The extrapolated onset temperature of the peak was 274.174°C. After the experiment, a yellow spread out residue remained in the sample container.
During Experiment 3 a closed sample container was used to investigate the nature of the endothermic peak. During heating a small exothermic followed by an endothermic effect was observed between 150°C and 350°C. The extrapolated onset temperature of the endothermic peak was 321.428°C. After the experiment, the sample container was swollen. This was most likely due to the high pressure generated during the evaporation of the test item. The small exothermic signal might have been caused by a degradation reaction only occurring at elevated pressure. The fact that the endothermic signal was observed at higher temperatures when a closed sample container was used, indicated that the effect was most likely caused by boiling. After the experiment, a brown spread out residue remained in the sample container.
Experiment 4 was performed with a similar temperature program as Experiment 2. Similar results as with Experiment 2 were obtained. The extrapolated onset of the boiling peak was 274.228°C. After the experiment, a yellow spread out residue remained in the sample container.
To confirm that the endothermic peak derived from boiling (especially as a brown residue remained in the sample container after Experiment 3) a higher heating rate of 50°C/minute was applied in Experiment 5. The extrapolated onset temperature of the endothermic peak was 274.828°C. The similar value demonstrated that boiling of the test item was the reason for the endothermic effect.
The boiling temperature was determined as the average boiling temperature obtained from experiment 2 (274.174°C), experiment 4 (274.228°C) and experiment 5 (274.828°C).
Applicant's summary and conclusion
- Conclusions:
- The boiling temperature of JNJ-126971-AAA (T000509) was determined at 274.4°C (547.6K) by using DSC.
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