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Diss Factsheets
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EC number: 211-317-0 | CAS number: 638-07-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion
A study was carried out according to EU Method B.4 and OECD Guideline 404 (acute dermal irritation) on three Albino rabbits. Sicne the test item was expected to produce severe skin effects, exposure periods of 3 minutes, 1 hour and 4 hours were exsamined. When applied for 4 hours, the test substance caused moderate erythema, severe haemorrhages, moderate (black) incrustation, and severe oedema in the one rabbit treated. At l4 and 2l days atler treatment, scar tissue was observed.When applied for 1 hour, the test substance caused moderate erythema, slight haemorrhages (one rabbit), slight incrustation, and severe oedema in the three rabbits treated. At 21 days after treatment, scar tissue was observed in one rabbit and decreased hair growth in the other two rabbits. When applied for 3 minutes, the test substance caused well-defined or moderate erythema and severe oedema in the three rabbits trcated. At 2l days after treatment, all skin effects had cleared completely. 3. On the basis of the results obtained under the conditions of this study and according to the EC-standards, it was concluded that:
- P0026 is irritating, but not corrosive after a 3-min exposure period,
- P0026 is irritating and corrosive after a 1 -hour exposure period, and
- P0026 is irritating and corrosive after a 4-hour exposure period.
Eye irritation/corrosion
The test item was examined for eye irritating/corrosive potential in an ex vivo bioassay, namely the Enucleated Eye Test with chicken eyes (GEET). The chicken eyes were obtained from slaughter animals for human consumption. The sample caused severe corneal swelling, moderate to severe corneal opacity and moderate fluorescein retention of damaged corneal epithelium in the test eyes. On the basis of the results obtained with this ex vivo bioassay and according to the CEET scheme for (EC-)classification applied, it was concluded that the substance was severely irritating to eyes. In addition, a subsequent in vivo dermal toxicity study with rats and a sensitization study with guinea pigs also showed skin corrosivity by the test substance. It was therefore, decided not to carry out the in vivo eye irritation test with rabbits but to consider the test substance causing serious damage to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the results of the two studies, the test item needs to be classified as follows:
Skin corrosion cat.1B - H314: Causes severe skin burns and eye damage
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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