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Diss Factsheets
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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: repeated dose (eight daily doses)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: abstract available, no information about purity of the test substance
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of methoxyacetic acid in male rats
- Author:
- Miller RR, Carreon RE, Young JT, McKenna MJ
- Year:
- 1 982
- Bibliographic source:
- Fundam Appl Toxicol, 2: 158-160.
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- No data given.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data given.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data given.
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- eight daily doses.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 30, 100 or 300 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- Five animals.
Results and discussion
Results of examinations
- Details on results:
- At 100 and 300 mg/kg bw/d, there was a significant dose-dependent reduction in the absolute and relative thymus weight, the erythrocyte count, and the haemoglobin and haematocrit level (p < 0.05 in each case). In the high dose group from the 5th day of administration there were significant reductions in body weight, absolute and relative spieen and testes weights, and leucocyte count (p < 0.05 in each case). The following effects were seen at 100 and 300 mg/kg bw/d, on histological examination: loss of thymocytes in the thymic cortex and atrophy of the germ cells in the seminiferous tubules („degeneration of testicular germinal epithelium"). The high dose led to reduced cell density in the bone marrow and giant cell formation in the testes. Granulopoiesis, erythropoiesis and thrombopoiesis were not affected. The spieen was not examined in this study.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Male F344 rats received 8 daily gavage administrations of 0, 30, 100 or 300 mg Methoxyacetic acid/kg bw over a 2-week period. At the two highest dose levels, absolute and relative thymus weights, RBC, Hb and Hct values were significantly decreased. In the 300 mg/kg bw group, there was a decrease of body weight, absolute and relative spleen and testicular weights, and leukopenia. Cellularity of thymus core and germinal epithelium were affected at 100 mg/kg bw and above. Testicular giant cells and reduced cellularity in bone marrow were observed at 300 mg/kg bw, whereas doses of 30 mg/kg bw produced no effects within the observation period (Miller et al., 1982).
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