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Diss Factsheets
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EC number: 233-433-0 | CAS number: 10163-15-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No study was selected since studies for all 3 in vitro genotox endpoints were negative.
Short description of key information:
In vitro gene mutation study in bacteria: Two studies are available for this endpoint;
- The GLP key study (Thompson 2010) is conducted according to OECD guideline 471. Under the conditions of this test, disodium fluorophosphate was considered to be non-mutagenic.
- A supporting study (Gocke 1981) is not conducted according to modern day standards and is therefore not considered as reliable evidence for this endpoint. Nevertheless, the published data supports the conclusions made in the key study.
In vitro cytogenicity study in mammalian cells: A single key study is available for this endpoint.
- The non-GLP key study (Ishidate 1988) is comparable to the current guideline (OECD 473) with acceptable restrictions. Under the conditions of this test, disodium fluorophosphate was considered to be non-clastogenic.
- In vivo studies (described below) support the findings made in the key study.
In vitro gene mutation in mammalian cells: A single key study is available for this endpoint.
- The key study (Flanders 2010) is conducted under the conditions of GLP and according to OECD guideline 476. Under the conditions of this test, disodium fluorophosphate was considered to be non-mutagenic.
In vivo cytogenicity study in mammalian cells: Two studies are available for this endpoint;
- The non-GLP key study (Gocke 1981) is equivalent to OECD guideline 475 with acceptable restrictions. Under the conditions of this test disodium fluorophosphate was considered to non-clastogenic, thus supporting the results obtained in the in vitro analysis.
- The supporting study (Hayashi 1988) is not considered to be sufficient as key data. The authors reported that the test material non-clastogenic.
In vivo gene mutation studies:
- The supporting study (Buchi 1981) is not considered to be sufficient as key data. The authors reported no mutagenic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
In accordance with Regulation (EC) No 1272/2008, no classification for in vitro genetic toxicity is proposed because reliable in vitro studies in bacterial and mammalian cell lines indicated that the test material is negative for mutagenicity and clastogenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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