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EC number: 250-379-3 | CAS number: 30899-62-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 202), read across.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) was conducted.
The target substance is mainly characterized as a triester of glycerol esterified with acetic acid and lauric acid. A structurally very similar substance was selected as source substance. Glycerides, C8-21 and C8-21-unsatd. mono- and di-, acetates (CAS 97593-30-1) is a multi-constituent substance described as a triester of glycerol with acetic acid and lauric acid in a slightly different composition compared to the target substance. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the source substance Glycerides, C8-21 and C8-21-unsaturated, mono- and di-, acetates (CAS 97593-30-1) to aquatic invertebrates was performed according to OECD Guideline 202 (GLP) (Weyers, 2007). Daphnia magna was exposed to the test substance within a semi-static water exposure regime at 21 ± 1 °C. The study was performed as a limit test with a nominal loading rate of 100 mg/L. Nominal loadings were verified by GC/MS analysis. After 48 hours, abnormal swimming behaviour was observed in the treatment group but no immobilization was reported in treatment or control groups and therefore, the EL50 (48 h) was determined to be > 0.108 mg/L (measured concentration).
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure and composition, it can be concluded that Lauric acid ester with hydroxypropanediyl diacetate will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
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