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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-04-11 to 2013-05-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to OECD guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Indate (2-), hexachlorododeca-µ-methoxy-µ6-oxohexa-, hydrogen, compd. with N-methylmethanamine (1:2:2)
- Cas Number:
- 1381802-10-3
- Molecular formula:
- [In6O(OMe)12Cl6]2–[NH2Me2]+2 · 2MeOH
- IUPAC Name:
- Indate (2-), hexachlorododeca-µ-methoxy-µ6-oxohexa-, hydrogen, compd. with N-methylmethanamine (1:2:2)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Batch number V107 – V110
Purity > 99 %
Molecular weight 1446.302 g/mol
Appearance Colorless, crystalline powder
Water solubility Reacts (sensitive to hydrolysis, t ½ (pH 7): approx. 5 minutes
ThOD* 0.59 mg O2/mg (calculated)
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- The sludge originated from the municipal sewage treatment plant in Hildesheim, Germany. Activated sludge from the sewage plant at Hildesheim is well suited as it receives predominantly municipal sewage and hardly any industrial chemical waste. The activated sludge was washed twice with autoclaved tap water. After the second washing the settled sludge was filled up with mineral salts medium and was maintained in an aerobic condition by aeration for 2.5 hours. Thereafter the sludge was homogenized with a blender. The supernatant was decanted and maintained in an aerobic condition by aeration with CO2-free air for 6 days. 10 mL/L were used to initiate inoculation.
Colony forming units in the test vessels: Approx. 107 - 108 CFU/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 130 mg/L
- Based on:
- ThOD/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- In the toxicity control the biodegradation achieved 87 % after 14 days. After 28 days the biodegradation came to 91 %. The validity criterion that the test item should not inhibit the biodegradation of the reference item was fulfilled
In the abiotic control no degradation (CO2 evolution / O2 consumption) was determined until day 28.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 92
- Sampling time:
- 28 d
- Details on results:
- Both test item replicates reached the 10 % level (beginning of biodegradation) within 1 day. The 60 % pass level was reached within 4 days by both test item replicates. After 28 days the mean biodegradation was 92 %.
After a test period of 28 days, the test item is classified as readily biodegradable within the 10-d-window and after 28 days.
BOD5 / COD results
- Results with reference substance:
- The pass level for ready biodegradation (> 60 % degradation) was reached by the functional control within 2 days. The validity criterion that the degradation should be > 60 % after 14 d was fulfilled. Stages of Biodegradation: The adaptation phase changed to degradation phase within 2 days (degradation > 10 %) and the biodegradation came to a maximum of 99 % on day 26.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item is classified as readily biodegradable within the 10-d-window and after 28 days.
- Executive summary:
The ready biodegradability of the test item was determined with non adapted activated sludge in the Manometric Respirometry Test for a period of 28 days. The study was conducted according to OECD guideline 301 F. The test item concentration selected as appropriate was130 mg/L, corresponding to a ThOD of 76.7 mg O2/L per test vessel. The degradation was followed by measuring the oxygen concentration. The biodegradation rate is therefore expressed as the percentage BOD (biological oxygen demand) and was calculated for each study day.
In order to check the activity of the test system sodium benzoate was used as functional control. The pass level > 60 % was reached within 2 days. The biodegradation reached a maximum of 99 % degradation on day 26. In the toxicity control containing both test and reference item 87 % degradation occurred within 14 days. After 28 days the biodegradation came to 91 %. The degradation of the reference item was not inhibited by the test item. In the abiotic control no degradation (CO2evolution / O2consumption) was determined until day 28.
Both test item replicates reached the 10 % level (beginning of biodegradation) within 1 day.The 60 % pass level was reached within 4 days by both test item replicates. After 28 days the mean biodegradation was 92 %. The validity criteria of the guideline are fulfilled.
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