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EC number: 688-147-2 | CAS number: 82428-30-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Propenoic acid, 2-methyl-, 7-oxabicyclo[4.1.0]hept-3-ylmethyl ester
- IUPAC Name:
- 2-Propenoic acid, 2-methyl-, 7-oxabicyclo[4.1.0]hept-3-ylmethyl ester
- Details on test material:
- CAS No. 82428-30-6
Appearance slight yellow liquid
Water solubility 3.35 g/L (20°C)
Molecular weight 196.25 g/mol
Formula C11H16O3
Density 1.079 g/mL at 20°C
Recommended storage Cool, protected from light
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 83.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: (CI: 63.2 - 105)
Any other information on results incl. tables
Effect levels
|
Test duration [h] |
Nominal test item concentrations [mg/L] |
|
EC10 (with 95 % confidence limits) |
24 |
176 |
(Cl: 52.3 – > 200) |
48 |
11.0 |
(Cl: 7.26 – 19.0) |
|
EC50 (with 95 % confidence limits) |
24 |
192 |
(Cl: 56.6 – > 200) |
48 |
83.4 |
(Cl: 63.2 – 105) |
|
EC100 |
24 |
> 200 |
|
48 |
200 |
|
|
NOEC |
48 |
12.5 |
|
LOEC |
48 |
25.0 |
|
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the nominal concentrations of the test item S-100; 3,4-Epoxycyclohexylmethyl methacrylate, the 48 h-EC50 for Daphnia magna was 83.4 mg/L (95 % confidence limits: 63.2 – 105 mg/L).
The NOEC after 48 h was 12.5 mg/L. The LOEC after 48 h was 25.0 mg/L. - Executive summary:
In the acute immobilisation test with Daphnia magna (STRAUS), the effects of the test item S-100; 3,4-Epoxycyclohexylmethyl methacrylate (batch number:12051006) were determined according to OECD 202 (2004) from 2014-10-21 to 2014-10-23 at Dr.U.Noack-Laboratorien, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany.
The study was conducted under semi-static conditions over a period of 48 h with 6 concentrations of the test item S-100; 3,4-Epoxycyclohexylmethyl methacrylatein the range of 6.25 - 200 mg/L, prepared with dilution water in a geometric series with a separation factor of 2.
The test item S-100; 3,4-Epoxycyclohexylmethyl methacrylateis a clear, pale yellow liquid with a water solubility of 3.35 g/L (20 °C).The tested solutions were clear throughout the exposure period.
Twenty daphnids were exposed to each concentration leveland the control.
The concentrations of the test item S-100; 3,4-Epoxycyclohexylmethyl methacrylate were analytically verified via HPLC-DAD at the start of the exposure intervals (0 and 24 h) and at the end of the exposure intervals (24 and 48 h) in all concentration levels and the control.
The measured concentrations of the test item at the start of the exposure intervals (0 and 24 h) were in the range of 98 to 101 % of the nominal values. At the end of the exposure intervals (24 and 48 h), the measured concentrations of the test item were in the range of 97 to 99 % of the nominal values.
The measured test item concentrations were all within ±20 % of the nominal concentrations. This indicates that the test item concentrations were successfully maintained for the duration of the test. Therefore, the effect levels given are based on the nominal concentrations of the test item S-100; 3,4-Epoxycyclohexylmethyl methacrylate.
The water quality parameters (i.e. pH-value and dissolved oxygen concentration), measured at the start (0 and 24 h) and at the end of the exposure intervals (24 and 48 h), were within the acceptable limits. The validity criteria of the test guideline were fulfilled.
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