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Diss Factsheets
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EC number: 235-243-3 | CAS number: 12138-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-11-20, 2002-03-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
-Source and lot.batch No. of test material: 16031/01
-Purity test date: >98% - Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- Stock Solution: The solution (100 mg/L test item were weighed out) was applied to 1 L test medium
Dispersion Treatment: The stock solution was shaken with 20 upm for 24 h on a magnetic stirrer and filtrated with 0.45 um
Limit Concentration: 1:1 Saturated Solution (saturated concentration) - Test organisms (species):
- Scenedesmus sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: Scenedesmus subspicatus
- Strain/clone: CHODAT SAG 86.81
- Origin: Sammlung von Algenkulturen (SAG), Pflanzenphysiologisches Institut der Universitat Gottingen, Nikolausberger Weg 18, D-37073 Gottingen - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- Microscopic evaluation of the cells at the start and end of exposure
- Test temperature:
- 23.0 +/- 2.0 degrees
- Nominal and measured concentrations:
- The mean measured concentration was 245 ug Tungsten/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Plastic curvettes, transparant, with top, volume: 20mL
- No. of vessels per concentration (replicates): Three
- No. of vessels per control (replicates): Six
RANGE-FINDING STUDY
A preliminary range finding test was conducted under static conditions. 100 mg/L were weighed out, stirred 24 h and fitered with 0.45 before using. THree dilutions (1:1, 1:10, 1:100) of the stock solutions were carried out and used for the preliminary test. - Reference substance (positive control):
- yes
- Remarks:
- Potassium Dichromate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 245 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 245 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- The EC 50 Values of the reference item potassium dichromate after 72 h met the validity criteria according to EEC Method C.3 Annex 2
- Validity criteria fulfilled:
- yes
- Conclusions:
- In this study tungsten disulphide was not found to inhibit the biomass growth of the freshwater green algae Scenedesmus subspicatus at the saturated solution level corresponding to the concentraton of 245 ug tungsten/L
- Executive summary:
There is toxicity to aquatic algae and cyanobacteria data currently available for tungsten disulphide. The acute toxicity of tungsten disulphide to the unicellular freshwater green alga Scenedesmus subspicatus was determined according to the principles of OECD-Guideline 201 and EEC Directive 92/69/EEC Method C.3. The study was conducted under static conditions over the duration of 72 hours with an initial cell density of nominally 10e4 cell/mL. A saturated stock solution as limit concentration of the test item was tested. Three replicates were tested but the limit concentration and six replicates for control. Microscopic evaluation of the cells at the start and end of the incubation period revealed no morphological abnormalities. The mean concentration for tungsten was 245 ug/L at the saturated solution.
Results based on 95% confidence interval are: EbC50 at 72h: >245 ug/L; NOEC at 72h: 245 ug/L, and ErC50 at 72: >245 ug/L In this study tungsten disulphide was not found to inhibit the biomass growth of the freshwater green algae Scenedesmus subspicatus at the saturated solution level corresponding to the concentration of 245 ug tungsten/L.
Reference
Description of key information
There is toxicity to aquatic algae and cyanobacteria data currently available for tungsten on disulphide which will be used for read-across purposes. The acute toxicity of tungsten disulphide to the unicellular freshwater green alga Scenedesmus subspicatus was determined according to the principles of OECD-Guideline 201 and EEC Directive 92/69/EEC Method C.3. The study was conducted under static conditions over the duration of 72 hours with an initial cell density of nominally 10* cell/mL. A saturated stock solution as limit concentration of the test item was tested. Three replicates were tested but the limit concentration and six replicates for control. Microscopic evaluation of the cells at the start and end of the incubation period revealed no morphological abnormalities. The mean concentration for tungsten was 245 ug/L at the saturated solution.
Results based on 95% confidence interval are: EbC50 at 72h: >245 ug/L, NOEC at 72h: 245 ug/L, and ErC50 at 72: >245 ug/L
In this study tungsten disulphide was not found to inhibit the biomass growth of the freshwater green algae Scenedesmus subspicatus at the saturated solution level corresponding to the concentration of 245 ug Tungsten/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 245 µg/L
- EC10 or NOEC for freshwater algae:
- 245 µg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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