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EC number: 700-890-7 | CAS number: 503614-91-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 9 to 30, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Remarks:
- ENV/MC/CHEM(98)17 and 1999/11/EC
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate
- EC Number:
- 700-890-7
- Cas Number:
- 503614-91-3
- Molecular formula:
- C27 H28 N4 O5
- IUPAC Name:
- ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate
- Details on test material:
- Powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hsd:Sprague-Dawley(CD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England
- Age at study initiation: 5 - 7 weeks
- Weight at study initiation: 103 to 136 g
- Fasting period before study: overnight prior to, and 4 hours after, dosing.
- Housing: 3 of the same sex in metal cages with wire mesh mesh floors
- Diet: Standard lab rodent diet, ad libitum
- Water: tap water, ad libitum
- Acclimation period: minimum of 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3°C
- Humidity: 40-70 %
- Photoperiod (hrs dark / hrs light):12 hrs artificial light (06:00 - 18:00 hours in each 24hr period.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% methyl cellulose solution
- Details on oral exposure:
- by oral gavage using a plastic syringe and catheter (8 ch).
- Doses:
- dose level: 2,000 mg/kg
- No. of animals per sex per dose:
- 3 females plus 3 males per dose
- Control animals:
- no
- Details on study design:
- The cages of the rats were checked at least twice daily for any mortalities.
Animals were observed soon after dosing and at frequent intervals for the remainder of day 1. On subsequent days animals were observed once in the morning and at the end of each experimental day (with the exception of day 15 - morning only).
All animals were observed for 14 days after dosing.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths following a single oral gavage dose to a group of 6 rats (3 male/3 female) at a dose level of 2,000mg/kg bodyweight.
- Clinical signs:
- other: 1 female, on day 1, showed signs of piloerection. Recovery was complete by day 2.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material was greater than 2000 mg/kg bodyweight
- Executive summary:
The acute oral lethal dose (LD50) to rats of BMS 589154 -01 was demonstrated ot be greater than 2,000 mg/kg bodyweight.
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