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Diss Factsheets
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EC number: 204-052-7 | CAS number: 114-70-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed publications
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on benzyl acetate
- Author:
- D. McGinty , D. Vitale, C.S. Letizia, A.M. Api
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S363–S384
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of benzyl acetate in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzyl acetate
- EC Number:
- 205-399-7
- EC Name:
- Benzyl acetate
- Cas Number:
- 140-11-4
- Molecular formula:
- C9H10O2
- IUPAC Name:
- benzyl acetate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Benzyl acetate
- Molecular formula: C9H10O2
- Molecular weight: 150.176 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: c1(COC(C)=O)ccccc1
- InChl: 1S/C9H10O2/c1-8(10)11-7-9-5-3-2-4-6-9/h2-6H,7H2,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Benzyl acetate
- Molecular formula: C9H10O2
- Molecular weight: 150.176 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: c1(COC(C)=O)ccccc1
- InChl: 1S/C9H10O2/c1-8(10)11-7-9-5-3-2-4-6-9/h2-6H,7H2,1H3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- other: alcohol SDA 39
- Controls:
- yes
- Amount / concentration applied:
- 0.1-mL aliquot of 3%, 7.5% or 18.7% benzyl acetate in alcohol SDA 39
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- The observation period was once every 24 h for the first 4 days and at day seven.
- Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- The left eye of the rabbits served as the control.
SCORING SYSTEM: The eyes were scored according to the Draize scale
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 10 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- 7.5% in Alcohol SDA 39
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- 3% in Alcohol SDA 39
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- 18.7% in Alcohol SDA 39
- Irritant / corrosive response data:
- Using alcohol SDA 39 as the vehicle, conjunctival irritation was seen in all rabbits and corneal effects in one in three rabbits of each study. By the end of the 10th day the irritation had cleared at 3% and 18.7% but not at 7.5%.
Any other information on results incl. tables
Table: Results of the eye irritation study in rabbits
Dose(%) |
Vehicle |
Reactions |
3 |
Alcohol SDA 39 |
Conjunctival irritation in all rabbits, corneal effects in 1 of 3 rabbits |
7.5 |
Alcohol SDA 39 |
Conjunctival irritation in all rabbits, corneal effects in 1 of 3 rabbits |
18.7 |
Alcohol SDA 39 |
Conjunctival irritation in all rabbits, corneal effects in 1 of 3 rabbits |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Using alcohol SDA 39 as the vehicle, conjunctival irritation was seen in all rabbits and corneal effects in one in three rabbits of each study. By the end of the 10th day the irritation had cleared at 3% and 18.7% but not at 7.5%.
Hence,Benzyl acetate can be considered to be irritating to rabbit eyes - Executive summary:
An eye irritation study was conducted on chemical benzyl acetate. It was exposed to right eye of 3 albino rabbits for 24 hours using a 0.1-mL aliquot of 3%, 7.5% or 18.7%
benzyl acetate in alcohol SDA 39.The left eye of the rabbits served as the control. The observation period was once every 24 h for the first 4 days
and at day seven. The eyes were scored according to the Draize scale. Using alcohol SDA 39 as the vehicle, conjunctival irritation was seen in all rabbits and corneal effects in one in three rabbits of each study. By the end of the 10th day the irritation had cleared at 3% and 18.7% but not at 7.5%. Hence,Benzyl acetate can be considered to be irritating to rabbit eyes
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