Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-492-1 | CAS number: 1135-40-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP -guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see 'Principles of method if other than guideline'
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see 'Principles of method if other than guideline'
- Principles of method if other than guideline:
- Following the guideline, at least five times the amount which was determined in the preliminary study should be used for the main test. In this case, the mixtures with this loading rate did not deliver a filterable solution. The deviation is considered as uncritical, as several prepared solutions were saturated with test item.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 184 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 6
- Remarks on result:
- other: mean value ± standard deviation: 184.0 ± 5.6 g/L at 20.0 ± 0.5 °C
- Conclusions:
- Interpretation of results: very soluble (> 10000 mg/L)
Water solubility (at pH~6) = 184.0 ± 5.6 g/L at 20.0 ± 0.5 °C (mean value ± standard deviation)
The study was performed according to OECD TG105 and EU Method A.6 with only minor deviations considered as uncritical and therefore reliability of Klimisch 1 has been assigned. - Executive summary:
The water solubility of the test substance was determined (from measured concentrations in the filtrated and diluted test solutions) to be 184 g/L (mean value) at 20 °C and pH~6 in a GLP test according to OECD 105 resp. EU A.6 (flask method).
According to the guideline fivefold saturation of the test item water mixture for the main test is proposed. Because the mixture with nominal concentration 1000 g/L resulted in a high amount of dry test item and no filterable solution, a further pre-test was performed to find the highest possible loading rate. As the mixture with nominal load 542 g/L showed sufficient filterable solution, loading rates of 450 – 560 g/L were chosen for the main test.
During equilibration sampling was performed three times. The samples of the third sampling showed after sample preparation strongly scattering results. It was assumed, that this was caused by sample preparation. The sample preparation was changed therefore (dilution in two steps instead of one step). The precision was sufficient after this modification.
The modified sample preparation was applied to the samples of sampling 3 and sampling 4 (plateau). The samples of sampling 1 and sampling 2 were not taken into account for further evaluation, as they were regarded to be not reliable. The measurements of sampling 3 (7 – 9 days) showed, that equilibrium was achieved. On day 10 all flasks were sampled for the measurements at the plateau.
One measurement (flask 2) was stated as an outlier (Grubbs Test). The standard deviation of 5.6 g/L corresponding to a RSD of 3.1 % is sufficient.
No dependency of the solubility on the amount of the test item (nominal load) was perceived.
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
Reference
Description of key information
The water solubility at 20 °C of the test material was determined to be 184 g/L (very soluble) [OECD Guideline 105, EU Method A.6]
Key value for chemical safety assessment
- Water solubility:
- 184 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.