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EC number: 810-292-9 | CAS number: 1072-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-04-21 - 2015-05-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-methyl-1,3-oxazolidin-2-one
- EC Number:
- 810-292-9
- Cas Number:
- 1072-70-4
- Molecular formula:
- C4H7NO2
- IUPAC Name:
- 5-methyl-1,3-oxazolidin-2-one
- Details on test material:
- - Name of test material (as cited in study report): 5-methyl oxazolidin-2-one
- Physical state: Liquid/colorless, clear
- Analytical purity: 98.0 area-% (GC)
- Lot/batch No.: EWALD-00441
- Expiration date of the lot/batch: 19 Jan 2017
- Stability under test conditions: stable
- Storage condition of test material: at room temperature
- Water solubility: Miscible in any ratio
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum (location, sampling depth, contamination history, procedure): Municipal activated sludge from the wastewater treatment plant of Mannheim, Germany. The inoculum was collected on 20 April 2015 from the aeration tank of the plant. A suitable aliquot of the activated sludge suspension was sieved by a finely woven mesh with a mesh size about 1 mm. To reduce the content of inorganic carbon in the blank controls the activated sludge was aerated with carbon dioxide free air for about 24 hours at 22 ± 2° C.
- Preparation of inoculum for exposure: At the day of exposure the suspension was washed one time with drinking water. Therefore the aeration was stopped and the sludge was allowed to settle. After settling the supernatant was discarded and the remaining sludge suspension was filled up with drinking water and the concentration oft the sludge was adjusted to 6.0 g/L dry weight. Aliquots of 7.5 mL were added to the test vessels to obtain an activated sludge concentration of 30 mg/L dry weight. - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 20 mg/L
- Based on:
- other: TOC
- Initial conc.:
- 42 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: acccording to the guideline
- Test temperature: 22 ± 2° C.
Due to technical malfunction of the electricity supply the test temperature was
marginally above 24 °C for a short time. An impact to the test result can be excluded
- pH: 7.1 - 7.7
- pH adjusted: The pH-values in the test vessels were measured and adjusted to 7.4 ± 0.2, if
necessary
- Aeration of dilution water: the aeration was performed with carbon dioxide free air at a flow of approximately 800 mL per hour
TEST SYSTEM
- Culturing apparatus: 2 L incubation bottles
- Number of culture flasks/concentration: 2
- Measuring equipment: carbon dioxid trap
- Details of trap for CO2 and volatile organics if used: The bottles were connected to two serial scrubbing bottles (total
volume 250 mL) filled with 100 mL 0.05 mol sodium hydroxide solution for the
adsorption of carbon dioxide from biodegradation processes. Usually twice a week the
Total Inorganic Carbon (TIC) values of the adsorption solutions of the first trap were
determined and used for the calculation of the produced carbon dioxide. After each
sampling the second trap was moved forward and the new trap with fresh sodium
hydroxide solution was placed into the second position. Each trap was analyzed
separately.
SAMPLING
- Sampling frequency: Usually twice a week
CONTROL AND BLANK SYSTEM
-2 blank control assays (BC)
2 test substance assays (TS)
1 inhibition control test assay (IH)
1 reference substance assay (RS)
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 60 - 70
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Degree of biodegradation of the reference substance after 14 days: 71 % CO2/ThCO2
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The conclusion that 5-methyl oxazolidin-2-one was readily biodegradable in this
carbon dioxide evolution test based on the quantitative determination of the formed
carbon dioxide in the test substance assays by comparison with the calculated maximal
theoretical carbon dioxide production.
The required pass level for ready biodegradability within a ten days window was
reached.
The degree of biodegradation after an exposure period of 28 days was 60-70 %
CO2/ThCO2 in this test.
The degree of biodegradation was calculated as mean of the values from two test
assays at the end of exposure.
The results in this study are consistent with all validity criteria and the test is valid
according to the test guideline of this study. No deviations from the test guidelines or
other incidents occurred during the course of the reported test, which may have
influenced the results.
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