Formaldehyde, oligomeric reaction products with phenol

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Estimated data generated using the EPI Suite program developed by the USEPA.

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Prediction done using BCFBAF (v3.01) model

GLP compliance:

no

Radiolabelling:

no

Vehicle:

no

Test organisms (species):

other: Fish

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Test temperature:

25°C

Reference substance (positive control):

no

Key result

Temp.:

25 °C

Type:

BCF

Value:

8.142 L/kg

Basis:

whole body w.w.

Calculation basis:

other: Estimated

Remarks on result:

other: Non bioaccumulative

Details on results:

BCFBAF Program (v3.00) model of EPI suite used to estimate bioconcentration dactor of test chemical. BCF of test chemical was predicted to be 8.142 L/kg wet-wt at 25°C.

Validity criteria fulfilled:

no

Conclusions:

BCFBAF Program (v3.00) model of EPI suite used to estimate bioconcentration dactor of test chemical. BCF of test chemical was predicted to be 8.142 L/kg wet-wt at 25°C.

Executive summary:

Using BCFBAF Program (v3.00) model of EPI suite, bioconcentration factor (BCF) for test chemical was estimated to be 8.142 L/kg wet-wt at 25°c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.

Description of key information

BCFBAF Program (v3.00) model of EPI suite used to estimate bioconcentration dactor of test chemical. BCF of test chemical was predicted to be 8.142 L/kg wet-wt at 25°C.

Key value for chemical safety assessment

BCF (aquatic species):

8.142 L/kg ww

Additional information

Following different studies includes estimated study for the target chemical and experimental study for read-across analogues which is extracted by using mechanistic approach and functionally and structurally similar to the target chemical to observe the bioconcentration factor of test chemical.

Using BCFBAF Program (v3.00) model of EPI suite, bioconcentration factor (BCF) for test chemical was estimated to be 8.142 L/kg wet-wt at 25°c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.

Using Bio-concentration Factor (v12.1.0.50374) module, bio-concentration Factor of the test chemical was estimated to be 10.5, 10.0, 7.09, 1.81 and approx. 1 at pH range 0-8, 9, 10, 11 and 12-14, respectively which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.

Test was conducted to determine bioconcentration factor of test chemical. Study was carrried out for 28 days. Lepomis macrochirus of 0.37-0.94 g of weight and 25-32 mm of length was used as test organism. Test organisms were exposed to 0.01 mg/l concentration of test chemical to evaluate bioconcentration factor. Oxygen supply by high flow rate and therefore no additional ventilation required. Test vessel of 40x20x25 cm was used to perfom experiment. Test organisms were acclimitized for 30 days period of time and fed with dry food. The BCF of test chemical was determined to be 150 dimensionless, which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.

Test was conducted to determine bioconcentration factor (BCF) of test chemical. The BCF of test chemical was determined to be 35 dimensionless, which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.

Based on the above BCF values, it is concluded that test chemical is non-bioaccumulative in food chain.