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EC number: 218-817-8 | CAS number: 2243-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
1,5.naphthylenediamine (Alphamin) is of moderate acute oral toxicity:
In an acute oral study female Wistar rats were treated with one single dose of the test substance Alphamin (500; 550; 600; 800; 1000; 1500 mg/kg
bw.).
10 rats per dose group were treated and observed for 14 days.
Following symptoms were observed: narcosis, rough hair, diminuated general condition, weight loss after the first week of experiment.
No macroscopical pathological findings were observed in the authopsy.
The LD50 was 634 mg/kg bw. (Loeser 1981 a).
Male rats, were treated with one single dose of the test substance Alphamin (1500; 2000; 2500; 2800; 3100 mg/kg bw.).
10 rats per dose group and observed for 14 days.
Following symptoms were observed: narcosis, rough hair, diminuated general condition, weight loss.
No macroscopical pathological findings were observed in the authopsy.
The LD50 was 2100 mg/kg bw. (Loeser 1981 b)
In an acute inhalation toxicity study according to OECD guideline 403, 5 male and 5 female Wistar rats (170 -200g) per group were treated with the
test substance for 4 hours.
The observation period was 14 days.
Symptoms of toxicity observed were: reduced motility, decelerated breathing, ruffled hair (occurred in the second half of the first week of the
observation period); 2 females died after 4 days; macroscopical findings in female rats: hydrothorax, reddened renal pelvis, dark and enlarged
spleen, pale liver with marked lobules, reddened gastrointestinal tract.
The LC50 for male rats was > 5.27 mg/l.
The LC50 for female rats was ca. 5.27 mg/l.
The NOEL was 2.01 mg/l (Pauluhn 1988).
In an acute dermal toxicity study according to guideline 84/449/EWG, 5 male and 5 female Wistar-rats (median weight: 253, 197 g resp.) were
treated with 2000 mg/kg of the test substance (in Cremophor EL).
The application time was 24h and the observation period 14 days.
No systemic or local symptoms of toxicity were observed. The LD 50 was > 2000 mg/kg bw. (Bomhard 1988).
Key value for chemical safety assessment
Additional information
Acute toxicity: oral
Effect level: LD50 female rats: 634 mg/kg bw.
LD50 male rats: 2100 mg/kg bw.
Acute toxicity: dermal
Effect level: LD50: >2000 mg/kg bw.
Acute toxicity: inhalation
Effect level: LC50: >5,27 mg/l.
NOAEL: 2,01 mg/l.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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