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EC number: 214-968-9 | CAS number: 1229-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
Eye Irritation:
No mortalities or abnormal clinical signs were observed. Redness (grade 1 through 3), chemosis (grade 1 and 2), discharge (grades 1 and 2), and iritis (grade 1) were observed. Blistering of the conjunctivae was noted for all animals. All animals were considered to have exhibited a positive response to Solvent Red 1.
Hence, Solvent Red 1 can be considered to be irritating to New Zealand White rabbit eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of Solvent Red 1 in New Zealand White rabbits
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula: C17H14N2O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Sex: Male and female
- Source: Kuiper’s rabbit ranch, Gary, IN.
- Age at study initiation: No data available
- Weight at study initiation: 2.26 – 2.88 kg
- Fasting period before study: No data available
- Housing: Animals were housed in the appropriate randomly selected cage. Each animal was then assigned a sequential animal number unique within American Biogenics Corporation (ABC) and identified with an ear tag bearing this animal number, The sequential animal number was listed on a cage card that was affixed to the front of the animal's cage. Rooms were cleaned daily and the cages were cleaned and sanitized as specified in ABC SOP's. Urine and feces fell through the wire mesh floor onto animal caging board. The cage boards were changed at least 2 to 3 times per week.
- Diet (e.g. ad libitum): Purina Certified Rodent Chow 5002, ad libitum, except for fasting prior to dosing.
- Water (e.g. ad libitum): Filtered tap water was provided through an automatic watering system and was analyzed periodically, ad libitum.
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 7 °C
- Humidity (%): 30-70 %
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 6:00 a.m. to 6:00 p.m. (12 hour light/dark, cycle)
IN-LIFE DATES: From: October 15, 1985 To: October 29, 1985 - Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped intact and abraded skin
- Vehicle:
- physiological saline
- Controls:
- not specified
- Amount / concentration applied:
- Each rabbit received a dose of 0.5ml Solvent Red 1 on two intact sites and two abraded sites (the right anterior and the left posterior were abraded).
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Sites were scored at 24 and 72 hr. after application
- Number of animals:
- groups of 6 rabbits (3/sex)
- Details on study design:
- TEST SITE
- Area of exposure: Thoracic region of spinal column
- % coverage: No data available
- Type of wrap if used: 2.5 centimeter square gauze patch were used.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Each test site was gently wiped with gauze sponges moistened with an appropriate vehicle (known not to cause any dermal toxic reactions) to remove any remaining test article.
- Time after start of exposure: 24 hours
SCORING SYSTEM: The reactions were scored according to the method of Draize
The Primary Irritation Score was calculated for each test article as follows: the average scores for erythema and eschar formation for intact and abraded skin at 24 (+2) and 72 (+2) hours were added to the average scores for edema for intact and abraded skin at 24 (+2) and 72 (+2) hours. The total of the 16 values was divided by 8 to give the Primary Irritation Score. - Other effects / acceptance of results:
- no data available
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Solvent Red 1 was non-irritating.
- Interpretation of results:
- other: not irritating
- Conclusions:
- No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
- Executive summary:
The primary dermal irritation of Solvent Red 1 was assessed in rabbits. The backs of six New Zealand White (NZW) rabbits (three of each sex) were closely clipped 24 hours before dosing. Each rabbit received a dose of 0.5ml Solvent Red 1 on two intact sites and two abraded sites (the right anterior and the left posterior were abraded). After 24 hours of exposure, the wrappings and patches were removed and sites wiped off with gauze sponges moistened with water. Sites were scored at 24 and 72 hours after application using the method of Draize (1979).Each animal was weighed prior to application of each test article. All animals were observed at least once daily for mortality and obvious toxic signs.
No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
Reference
Table: Primary Dermal Irritation of Solvent Red 1
Animal Number |
Sex |
Initial Body Weight (kg) |
24(+2) hours**
|
72(+2) hours** |
|||||||||||||||
Intact |
Abraded |
Intact |
Abraded |
||||||||||||||||
Left |
Right |
Left |
Right |
Left |
Right |
Left
|
Right
|
||||||||||||
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
Ed |
Er |
ed |
||||
BB9374 |
Male |
2.56 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9375 |
Male |
2.86 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9422 |
Male |
2.86 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9403 |
Female |
3.10 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9439 |
Female |
2.74 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
BB9449 |
Female |
2.60 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
0r |
0 |
|
Total |
|
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Average |
|
|
(A) 0 |
(B) 0 |
(C) 0 |
(D) 0
|
(E) 0 |
(F) 0
|
(G) 0 |
(H) 0 |
(I) 0 |
(J) 0 |
(K) 0 |
(L) 0 |
(M) 0 |
(N) 0 |
(O) 0 |
(P) 0 |
|
**= after test article application
Er= erythema
Ed= edema
R= test site stained red
Primary Irritation Score = (A+B+C+D+E+F+G+H+I+J+K+L+M+N+O+P)/8
Primary Irritation Score = 0.0
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of Solvent Red 1 in New Zealand White rabbits
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 1-[(2-methoxyphenyl)diazenyl]-2-naphthol
- Common Name: Solvent Red 1
- Molecular formula: C17H14N2O2
- Molecular weight: 278.31 g/mol
- Smiles notation: c12c(\N=N\c3c(cccc3)OC)c(ccc1cccc2)O
- InChl : 1S/C17H14N2O2/c1-21-16-9-5-4-8-14(16)18-19-17-13-7-3-2-6-12(13)10-11-15(17)20/h2-11,20H,1H3/b19-18+
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: Male and female
- Source: Kuiper’s rabbit ranch, Gary, IN.
- Age at study initiation: No data available
- Weight at study initiation: 2.40 – 2.58 kg
- Fasting period before study: No data available
- Housing: Animals were housed in the appropriate randomly selected cage. Each animal was then assigned a sequential animal number unique within American Biogenics Corporation (ABC) and identified with an ear tag bearing this animal number, The sequential animal number was listed on a cage card that was affixed to the front of the animal's cage. Rooms were cleaned daily and the cages were cleaned and sanitized as specified in ABC SOP's. Urine and feces fell through the wire mesh floor onto animal caging board. The cage boards were changed at least 2 to 3 times per week.
- Diet (e.g. ad libitum): Purina Certified Rodent Chow 5002, ad libitum, except for fasting prior to dosing.
- Water (e.g. ad libitum): Filtered tap water was provided through an automatic watering system and was analyzed periodically, ad libitum.
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 7 °C
- Humidity (%): 30-70 %
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 6:00 a.m. to 6:00 p.m. (12 hour light/dark, cycle)
IN-LIFE DATES: From: September 16, 1985 To: September 24, 1985 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg (0.1 ml)
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- The treated eye of each animal was examined for ocular irritation and lesions at 24, 48 and 72 hours (+2 hours at each interval). The treated eyes were evaluated on days 7, 14, and 21 if irritation persisted.
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 6 (3/sex)
- Details on study design:
- Details on study design
TEST SITE
- Area of exposure: everted lower lid of the right eye
- % coverage: No data available
- Type of wrap if used: No data available
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available
SCORING SYSTEM: according to Draize method
The mean Primary Eye Irritation Score with standard deviation and standard error values were calculated at each evaluation interval using the total scores of each treated eye. - Other effects / acceptance of results:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 10.7
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 4.7
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.7
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Redness (grade 1 through 3), chemosis (grade 1 and 2), discharge (grades 1 and 2), and iritis (grade 1) were observed.Blistering of the conjunctivae was noted for all animals. Two animals also exhibited opacities and positive fluorescein staining.
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- No mortalities or abnormal clinical signs were observed. Redness (grade 1 through 3), chemosis (grade 1 and 2), discharge (grades 1 and 2), and iritis (grade 1) were observed. Blistering of the conjunctivae was noted for all animals. All animals were considered to have exhibited a positive response to Solvent Red 1.
Hence, Solvent Red 1 can be considered to be irritating to New Zealand White rabbit eyes. - Executive summary:
An eye irritation study was performed on 6 (3/sex) New Zealand White Albino rabbits to assess the irritation potential of Solvent Red 1.
0.1 g of neat Solvent Red 1 was instilled into the eyes of rabbits and the effects were observed. The treated eye of each animal was examined for ocular irritation and lesions at 24, 48 and 72 hours (+2 hours at each interval). The treated eyes were evaluated on days 7, 14, and 21 if irritation persisted. No mortality and clinical signs of toxicity were observed in treated rabbits. Redness (grades 1 through 3), chemosis (grades I and 2), discharge (grades 1 and 2) and iritis (grade 1) were observed. Blistering of the conjunctivae were observed.Blistering of the conjunctivae was noted for all animals. Two animals also exhibited opacities and positive fluorescein staining. All animals were considered to have exhibited a positive response to Solvent Red 1.
The mean irritation score after 72 hours was 0.7
Hence, Solvent Red 1 can be considered to be irritating to New Zealand White rabbit eyes.
Reference
Table 1: Ocular reaction data
|
Time interval |
Prior to instillation |
24 (± 2) hours |
48 (± 2) hours |
72 (± 2) hours |
||||||||
|
No of animals |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
2 |
3 |
1 |
Cornea |
|
|
|
|
|
|
||||||
|
Density |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Area |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
A x B x 5 |
0 |
0 |
0 |
5 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
Iris |
|
|
|
|
|
|
|
|
|
|
|
|
|
Value |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
A x 5 |
0 |
0 |
0 |
5 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3 |
Conjunctivae |
|
|
|
|
|
|
|
|
|
|
|
|
|
Redness |
0 |
0 |
0 |
3 |
2 |
2 |
2 |
1 |
1 |
1 |
0 |
0 |
|
Cherosis |
0 |
0 |
0 |
2 |
2 |
2 |
1 |
0 |
1 |
0 |
0 |
0 |
|
Discharge |
0 |
0 |
0 |
2 |
1 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
(A + B+ C) x 2 |
0 |
0 |
0 |
14 |
10 |
12 |
6 |
2 |
4 |
2 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total 1 +2 +3 |
0 |
0 |
0 |
24 |
10 |
22 |
6 |
2 |
4 |
2 |
0 |
0 |
|
Reaction to fluorescein |
|
|
|
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Mean |
0 |
0 |
0 |
10. 7 |
4.0 |
0.7 |
||||||
|
S.D. |
0 |
0 |
0 |
7.5 |
2.0 |
1.2 |
||||||
|
S.E. |
0 |
0 |
0 |
4.4 |
1.2 |
0.7 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
In different studies, Solvent Red 1 has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with predicted data for target chemical and its structurally similar read across substances, 1-(phenylazo)-2-napthol [CAS: 842-07-9].
Primary skin irritation study was conducted by Gunda Reddy and Dale A. Mayhew (International Journal of Toxicology, Vol 15, Issue 1_suppl, pp. S43 - S44, 1996) on 6 New Zealand White rabbits to assess the irritation potential of Solvent Red 1. The backs of six New Zealand White (NZW) rabbits (three of each sex) were closely clipped 24 hours before dosing. Each rabbit received a dose of 0.5ml Solvent Red 1 on two intact sites and two abraded sites (the right anterior and the left posterior were abraded). After 24 hours of exposure, the wrappings and patches were removed and sites wiped off with gauze sponges moistened with water. Sites were scored at 24 and 72 hours after application using the method of Draize (1979).Each animal was weighed prior to application of each test article. All animals were observed at least once daily for mortality and obvious toxic signs.
No mortalities or abnormal clinical signs were observed during the study. No dermal irritation was observed during the study. Solvent Red 1 scored 0.0 on the Primary Irritation Index. Hence, Solvent Red 1 was considered to be not irritating to rabbit skin.
This result is supported by the Primary skin irritation test of structurally similar read across substances, 1-(phenylazo)-2-napthol [CAS: 842-07-9] performed (BASF Aktiengesellschaft Gewerbehygiene und Toxikologie, 6700 Ludwigshafen, 1977) according to Guidelines mentioned in Federal Register 38 No 187 § 1500 .41 (skin). 6 rabbits were used for the study. 50% of the substance in aqueous solution was applied on the intact and scarified skin of rabbits and the effects were observed at 24 and 72 hours. The reactions were scored according to Draize method. Due to substance-induced coloration of the skin no reading and no exact calculation of the primary irritation was possible at 24 hours.
Skin lesions were also observed after 8 days of testing. No lesions were observed in case of intact skin, but dandruff formation was recorded in 4 of 6 rabbits in case of scarified skin.The Primary Skin Irritation Score of 1-phenylazo-2-naphthol was 0.17.
On the basis of the scores and observations, 1-phenylazo-2-napthol can be considered as not irritating to skin.
Based on the available data for the target and read across substances, Solvent Red 1 can be considered to be not irritating to skin.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Eye Irritation:
In different studies, Solvent Red 1 has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with predicted data for target chemical and its structurally similar read across substances, 1-({2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-2-naphthol (also known as Solvent Red 24) [CAS: 85-83-6] and 1-(4-(phenylazo)phenylazo)-2-naphthol also known as Solvent Red 23 [CAS:85-86-9].
Primary eye irritation study was conducted by Gunda Reddy and Dale A. Mayhew (International Journal of Toxicology, Vol 15, Issue 1_suppl, pp. S43 - S44, 1996) on 6 New Zealand White rabbits to assess the irritation potential of Solvent Red 1. 0.1 g of neat Solvent Red 1 was instilled into the eyes of 6 New Zealand White (NZW) rabbits (three of each sex) and the effects were observed. The treated eye of each animal was examined for ocular irritation and lesions at 24, 48 and 72 hours (+2 hours at each interval). The treated eyes were evaluated on days 7, 14, and 21 if irritation persisted. No mortality and clinical signs of toxicity were observed in treated rabbits. Redness (grades 1 through 3), chemosis (grades I and 2), discharge (grades 1 and 2) and iritis (grade 1) were observed. Blistering of the conjunctivae were observed.Blistering of the conjunctivae was noted for all animals. Two animals also exhibited opacities and positive fluorescein staining. All animals were considered to have exhibited a positive response to Solvent Red 1.
The mean irritation score after 72 hours was 0.7
Hence, Solvent Red 1 can be considered to be irritating to New Zealand White rabbit eyes.
This result is supported by the experimental summarized inScientific Committee on Cosmetology (seventh series), 1988; for thestructurally similar read across substance, 1-({2-methyl-4 -[(2-methylphenyl)diazenyl]phenyl}diazenyl)-2-naphthol (also known as Solvent Red 24) [CAS: 85-83-6].100 mg of Sudan IV was made into a paste with 8 drops of 1,2-propanediol and instilled into the rabbits eyes
The rabbits were observed (duration not specified) for ocular reactions to Sudan IV.
The dye was classified as slightly irritating to the mucous membranes.
These results are further supported by the experimental studyScientific Committee on Cosmetology (seventh series), for thestructurally similar read across substance, 1-(4-(phenylazo)phenylazo)-2-naphthol also known as Solvent Red 23 [CAS:85-86-9]. Upon application of 0.1 g Solvent Red 23 with 2 drops of propanediol to the rabbit eyes, Solvent Red 23 was considered to be slightly irritating to rabbit eyes.
Based on the available data for the target and read across substances, Solvent Red 1 can be considered to be irritating to eyes.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2”.
Justification for classification or non-classification
Available studies for Solvent Red 1 indicate that it is not likely to cause any irritation to skin and but it causes irritation to eyes.
Hence, Solvent Red 1 can be classified under the category “Not Classified” for skin and “Category 2” for eyes as per CLP.
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