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Diss Factsheets
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EC number: 208-561-5 | CAS number: 533-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Evaluation of sesamol-induced histopathological, biochemical,haematological and genomic alteration after acute oral toxicity infemale C57BL/6 mice
- Author:
- Evaluation of sesamol-induced histopathological, biochemical,haematological and genomic alteration after acute oral toxicity infemale C57BL/6 miceShahanshah Khana,b, Sandeep Choudharya, Arun Kumara, Akanchha Mani Tripathia,Amit Aloka, Jawahar Singh Adhikaria, Moshahid Alam Rizvib, Nabo Kumar Chaudhury
- Year:
- 2 016
- Reference Type:
- publication
- Title:
- Reports of the Scientific Committee on Cosmetology (ninth series)
- Author:
- EUROPEAN COMMISSION
- Year:
- 1 999
Materials and methods
- Principles of method if other than guideline:
- Twelve-mice were divided randomly into four equalgroups based on the OECD-423 guideline.
Test animals
- Species:
- other: mice
- Strain:
- C57BL
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The temperature and humidity weremaintained at 22 ± 2◦C and 50% humidity under a 12-h light/darkcycles respectively.
Administration / exposure
- Route of administration:
- other: oral
- Details on oral exposure:
- Experimental design:
The mice were randomly divided into 4 groups, of 3 mice eachas follows:
- Group-I: Control group animals received no treatment.
- Group-II: Sesamol 2000 group animals received 2000 mg/kgbody weight of freshly prepared sesamol.
- Group-III: Sesamol 300 group animals received 300 mg/kg bodyweight of freshly prepared sesamol.
- Group-IV: Sesamol 300 confirmatory group animals received300 mg/kg body weight of freshly prepared sesamol. - Control animals:
- yes
Results and discussion
- Other findings:
- Oral LD50 = 300-2000 mg/Kg
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- ConclusionsThis study was conducted in accordance with the OECD-423guideline. From the observations in the present study, sesamolshould be placed under GHS category 4 (>300–2000) with LD50cut-off value of 500 mg/kg in female C57BL/6 mice.
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