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EC number: 257-827-7 | CAS number: 52301-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of the substance was found to be greater than 5000 mg/kg bw, while the dermal LD50 was >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- None
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 weeks
- Weight at study initiation: 220 g (males) and 166 g (females)
- Diet (e.g. ad libitum): Dakes special diet added with Vitamin E ad libitum
- Water (e.g. ad libitum): water was available at all times
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C (+/- 2°C)
- Photoperiod (hrs dark / hrs light): 12 hours artificial light and 12 hours darkness in each 24 hour period. - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- After administration of the compound, the animals were observed for 14 days. Deaths and clinical symptoms were recorded. At the end of the observation period, surviving animals were killed by exsanguination under ether anaesthesia and an autopsy performed.
- Doses:
- A 25 % w/v solution of the compound in tap water was administered as a single dose by gavage to rats which had been fasted for 18 hours, at a rate of 20 ml/kg. (equivalent to 5 g/kg of compound).
- No. of animals per sex per dose:
- Ten rats (5 M + 5 F) were used for the study.
- Control animals:
- no
- Details on study design:
- None
- Statistics:
- None
- Preliminary study:
- None
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality observed.
- Clinical signs:
- other: No clinical symptoms were recorded and no deaths occurred during the 14-day observation period.
- Gross pathology:
- At autopsy no changes in organs or tissues caused by the administration of the test compound were seen.
- Other findings:
- None
- Interpretation of results:
- other: Not classified as toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- The acute oral median lethal dose (LD50) of the substance in rats is greater than 5000 mg/kg body weight.
- Executive summary:
The test was performed to determine the acute oral toxicity of the substance according to the equivalent or similar OECD guideline 401 (Acute Oral Toxicity). It was tested on rats which were 6 to 7 weeks old and weighed about 166 to 220 g. No clinical symptoms were recorded and no deaths occurred during the 14 day observation period. At autopsy no changes in organs or tissues caused by the administration of the test compound were seen. In conclusion, the acute oral LD50 of the substance in rats of both sexes, observed over a period of 14 days is greater than 5000 mg/kg.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Clinical signs:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given, acceptable for assessment
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Kaninchen: Gelbsilber
Tierzahl, Sex/Dosis: 3M 3F
Tierzahl pro Käfig: 1
Tierhaltung: konventionell, klimatisierter Raum: Temperatur 23+2°C, relative Luftfeuchtigkeit 55+/- 5%, 14 Lichtstunden/Tag
Futter: Nafag Würfel Nr. 84
Applikation: Enthaaren der Rückenhaut durch Scheren.
Einmalige Applikation auf intakte Haut. Occlusiv-Verband (Methode
nach Draize) während 24 Stunden.
Abwaschen der Applikationsfläche mit lauwarmem Wasser und Schwamm.
Fläche: 200 - 300cm2
Volumen: 2.5 ml/kg
Beobachtungszeit: 8 Tage
200-300 cm2
2,5 ml/kg
8 Tage - Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- None
- Duration of exposure:
- None
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 M and 3 F
- Control animals:
- not specified
- Details on study design:
- None
- Statistics:
- None
- Preliminary study:
- None
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: 2000 mg/kg: 6/6: day 1-8: no symptoms related to resorption 24 h; 4/6: Erythema 2.-6. Tag: 6/6: no observations 7.+8. Tag: 1/6: scaling
- Gross pathology:
- None
- Other findings:
- None
- Interpretation of results:
- other: Not classified as toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- The acute dermal LD50 of the test substance the substance was found to be >2000 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the substance was performed on rabbits. However, no mortality was observed throughout the observation period. Hence, the acute dermal LD50 of the test substance was found to be >2000 mg/kg bw.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The animal studies demonstrated that the test item has low oral toxicity.
The key study describing the acute oral toxicity did not find any mortality up to the maximum dose tested. Hence, the acute LD50 was found to be >5000 mg/kg bw.
In a supporting study describing the acute oral toxicity of the test item, no mortality was observed even at the maximum dose tested, hence the LD50 is considered to be > 15000 mg/kg bw.
Similar to acute oral toxicity data, the available animal acute dermal toxicity study demonstrated that the substance has low dermal toxicity. The key study describing the acute dermal toxicity of the substance did not find lethality up to the maximum dose tested and the LD50 was >2000 mg/kg bw.
Justification for classification or non-classification
Based on the above stated assessment of the acute oral toxicity thesubstance does not need to be classified for Acute Oral toxicity according to CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
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