Registration Dossier
Registration Dossier
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EC number: 944-536-1 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.8
- Temp.:
- 35 °C
- Remarks on result:
- other: Mean of 2 runs
- Type:
- Pow
- Partition coefficient:
- 6 850
- Temp.:
- 35 °C
- Remarks on result:
- other: Mean of 2 runs
- Conclusions:
- The log Pow of the test item was determined to be 3.8 at 35°C.
- Executive summary:
The partition coefficient of the test item was determined by HPLC method according to OECD TG 117. A calibration curve was constructed from the retention time data of thiourea and six reference standard solutions. The log Pow was determined to be 3.8 at 35°C, and it was calculated by HPLC calibration curve. This study is reliable with restrictions (reliability of 2) as it followed an accepted guideline, but was not GLP-compliant.
Reference
Table 1. Test results per injection of the test item
| Injection | Retention time (min) | Capacity Factor (k) | Log10k | Log10Pow |
| 1 | 3.695 | 1.02 | 0.01 | 3.8 |
| 2 | 3.702 | 1.02 | 0.01 | 3.8 |
| Average | 3.699 | 1.02 | 0.01 | 3.8 |
Description of key information
The log Pow of the test item was determined to be 3.8 at 35°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.8
- at the temperature of:
- 35 °C
Additional information
The partition coefficient of the test item was determined by the HPLC method according to OECD TG 117. The study is a guideline, non-GLP experimental study available as an unpublished report and is adequate for assessment of this endpoint (2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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