Registration Dossier
Registration Dossier
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EC number: 202-068-9 | CAS number: 91-44-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Only 0.5 and 1% tested.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Patch test with 102 volunteers exposed to 0.5 and 1% test substance
- GLP compliance:
- no
Test material
- Reference substance name:
- 7-(diethylamino)-4-methyl-2-benzopyrone
- EC Number:
- 202-068-9
- EC Name:
- 7-(diethylamino)-4-methyl-2-benzopyrone
- Cas Number:
- 91-44-1
- Molecular formula:
- C14H17NO2
- IUPAC Name:
- 7-(diethylamino)-4-methyl-2H-chromen-2-one
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in study report: Ciba compound 33185 / FAT 66005/11
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 102- Sex: 26 males and 76 females- Age: 13 - 76
- Clinical history:
- History of allergy or casuistics for study subjects:- Reacts to some detergents: 4 subjects - Reacts to some face powders and adhesive plaster: 1 subject- Reacts to plaster: 3 subjects- Irritable skin: 1 subject- Has had eczma: 2 subjects- "Nervous" eczma: 1 subject- Eczma of hands: 1 subject- Eczma of hands. Does not use detergents: 1 subject- Eczema of feet: 1 subject- Reacts to some powders: 1 subject- Dry skin: 2 subjects- Reacts to some cosmetics detergents and plants: 1 subject- Reacts to acriflavine: 1 subject
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TESTS USED: patch test (epicutaneous test)ADMINISTRATION - Concentrations: 0.5% and 1% in white soft paraffin - Patches were left on for 48 hours. - A second or "challenge" application was made to all of these same people after an interval of two or three weeks (the variation in interval between applications was simply a matter of convenience of carrying out the tests).
Results and discussion
- Results of examinations:
- There were no positive reactions to suggest that the powder was either primary irritant or sensitizers.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
