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EC number: 204-841-6 | CAS number: 127-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity study of the test chemical
- Author:
- Jenner et al
- Year:
- 1 964
- Bibliographic source:
- Fd Cosmet. Toxicol.
- Reference Type:
- publication
- Title:
- Assessment Report - Test chemical
- Author:
- ADAMS et al.
- Year:
- 1 996
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- review article or handbook
- Title:
- Toxicity Studies on rodents
- Author:
- Richard J. Lewis
- Year:
- 1 989
- Bibliographic source:
- Food Additives Handbook
- Reference Type:
- publication
- Title:
- TOXICOLOGICAL EVALUATION OF TEST CHEMICAL
- Author:
- WORLD HEALTH ORGANIZATION
- Year:
- 1 984
- Bibliographic source:
- WORLD HEALTH ORGANIZATION
- Reference Type:
- publication
- Title:
- SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES
- Author:
- World Health Organization
- Year:
- 1 999
- Bibliographic source:
- World Health Organization
- Reference Type:
- publication
- Title:
- Toxicological Evaluation of Certain Food Additives
- Author:
- WHO
- Year:
- 1 980
- Bibliographic source:
- WHO
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 204-841-6
- EC Name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 127-41-3
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- Details on test material:
- - IUPAC Name: 4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one
- Common Name: alpha-Ionone
- InChI: 1S/C13H20O/c1-10-6-5-9-13(3,4)12 (10)8-7-11(2)14/h6-8,12H,5,9H2,1-4H3/b8-7+
- Smiles: C1([C@@H](C(=CCC1)C)\C=C\C(C)=O) (C)C
- Molecular formula:C13H20O
- Molecular weight :192.3 g/mole
- Substance type:Organic
- Physical state:Colorless oil, woody, violet odor
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Females (if applicable) nulliparous and non-pregnant: No data
- Age at study initiation: Young rats were used for the study
- Weight at study initiation: No data
- Fasting period before study: 18 hrs prior to treatment
- Housing: Animals were housed in cages
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: To: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4590 mg/Kg bw
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: No data
DOSAGE PREPARATION (if unusual): No data
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data - Doses:
- 4590 mg/kg bw
- No. of animals per sex per dose:
- 10 rats evenly divided by sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were maintained under close observation for recording toxic signs artd time of death. Such observation was continued until animals appeared normal and showed weight gaiu.
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No data - Statistics:
- LD50'S were computed by the method of Litchfield & Wilcoxon (1949).
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 590 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 3 880 - < 5 400
- Mortality:
- 50% mortality was observed at 4590 mg/kg bw. Death time was 4 hrs - 4 days
- Clinical signs:
- other: Depression, tremors
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose (LD50) value was considered to be 4590 mg/kg bw, when rats were treated with the given test chemical via oral gavage route of exposure.
- Executive summary:
Acute oral toxicity study was conducted for the test chemical using male and female Osborne Mendel rats at the dose concentration of 4590 mg/kg bw via oral gavage route of exposure. Groups of 10 young adult Osborne-Mendel rats evenly divided by sex were fasted for approximately 18 hr prior to treatment. Animals had access to water at all times, and the food was replaced in cages as soon as animals received their respective doses. All doses were given by intubation. All animals were maintained under close observation for recording toxic signs artd time of death. Such observations were continued until animals appeared normal and showed weight gain. The test chemical showed depression and tremors and the death time was 4 hrs to 4 days. 50% mortality was observed at 4590 mg/kg bw. Hence, the LD50 value was considered to be 4590 mg/kg bw, when rats was treated with the given test chemical via oral gavage route of exposure.
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