Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-976-4 | CAS number: 728-88-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4'-dimethyl-3-piperidinopropiophenone hydrochloride
- EC Number:
- 222-876-5
- EC Name:
- 2,4'-dimethyl-3-piperidinopropiophenone hydrochloride
- Cas Number:
- 3644-61-9
- Molecular formula:
- C16H23NO.HCl
- IUPAC Name:
- 1-[2-methyl-3-(4-methylphenyl)-3-oxopropyl]piperidinium chloride
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Duration of treatment / exposure:
- 28 day
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 0.5 other: g/animals
Results and discussion
Results of examinations
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- In the control and treated group both the intact and scarified skin surfaces were symptom-free during the treatment. No primary irritation was observed. In all animals a slight exfoliation occurred on both the intact and abraded skin surfaces, otherwise, the animals were free of symptoms. At histopathological evaluation signs of secondary irritation (lesion) was found in samples taken from the intact and scarified skin surfaces treated with Tolperione 15%gel.The change was reversible.
- Mortality:
- no mortality observed
Effect levels
- Remarks on result:
- other: not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
