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EC number: 248-492-8 | CAS number: 27489-62-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-28 - 1999-05-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- July, 17, 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Version / remarks:
- December 1992
- GLP compliance:
- yes
Test material
- Reference substance name:
- trans-4-aminocyclohexan-1-ol
- EC Number:
- 248-492-8
- EC Name:
- trans-4-aminocyclohexan-1-ol
- Cas Number:
- 27489-62-9
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 4-aminocyclohexanol
Constituent 1
- Specific details on test material used for the study:
- Description: white powderBatch 722Purity: not indicated by sponsor; treated as 100% puretest substance storage: at room temperature in the darkExpiry Date. 2000--04-08 (allocated by NOTOX, 1 year after receipt of the test substance)
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- freshly obtained from a municipal sewage treatment plant "Waterschap de Maaskant´, ´s-Hertogenbosch, the Netherlands
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 46 other: of 1000mg Trans-4-Aminocycloexanol/l
- Based on:
- ThCO2
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Preliminary study:
- Since the purity of Trans-4-Aminocyclohexanol was unkown, calculation of the theoretical TOC value was not possible. Therefore, this value was determined by analysis. prior to the biodegradation study the TOC concentration of a Trans-4-Aminocyclohexanol solution in milli-Q-water, prepared at 1000mg/l was determined.
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 0
- Sampling time:
- 2 d
- Details on results:
- The TOC concentration of the 1000mg/l trans-4-Aminocyclohexanol solution was 524.1+-12.51 ppm. based on the TOC concentration the Theoretical CO2 production (ThCO2) of the Trans-4 -Amonocyclohexanol solution was calculated to be 1.92mg CO2/ml. The concentration was 46mL of 1000mg/l trans-4-Aminocyclohexanol/l (A and B) in 2 litres test medium. Hence, the theoretical CO2 production following complete degradation was 8..3mg per 2 litres for A and B. The positive control obtained 80.2mg sodium acetate (ThCO2=1.07 mg CO2/mg) resulting in a theoretical CO2 production following complete degradation of 85.8mg per 2 litres. The toxicity control contained 80.2 mg sodium acetate and 46 mL of 1000mg Trans-4-Aminocyclohexanol mg/l in 2 litres of test medium. Hence, the theoretical CO2 production following complete degradation of Trans-4-Aminocyclohexanol plus sodium acetate was 174.1 mg per 2 litres.
BOD5 / COD results
- Results with reference substance:
- The positive control substance was degraded at least 60% within 7 days. The total CO2 release in the blank reached a total value of 36mg CO2 per 2 litres of medium. The difference of duplicate values for %-degradation of Trans-4-Aminocyclohexanol was always less than 20. Since all criteria for acceptability of the test were met, this study was considered to be valid.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Trans-4-Aminocyclohexanol was not readily biodegradable under the conditions of the modified Sturm test presently performed.
- Executive summary:
Since the purity of Trans-4-Aminocyclohexanol was unkown, calculation of the theoretical TOC value was not possible. Therefore, this value was determined by analysis. prior to the biodegradation study the TOC concentration of a Trans-4-Aminocyclohexanol solution in milli-Q-water, prepared at 1000mg/l was determined.
The TOC concentration of the 1000mg/l trans-4-Aminocyclohexanol solution was 524.1+-12.51 ppm. Based on the TOC concentration the Theoretical CO2 production (ThCO2) of the Trans-4 -Amonocyclohexanol solution was calculated to be 1.92mg CO2/ml.
In the modified Sturm test 46ml of the Trans-4 -Amonocyclohexanol solution was tested in 2 litres test medium, corresponding to 12mg TOC/l.
The relative degradation values calculated from the measurements performed during the test period revealed no significant degradatioon of Trans-4 -Amonocyclohexanol. In the toxicity control Trans-4 -Amonocyclohexanol was fount to be not inhibitory.
Since all acceptability criteria prescribed by the protocol were me, this study was considered to be valid.
In conclusion, Trans-4 -Aminocyclohexanol was not readily biodegrable under the conditions of the modified Sturm test presently performed.
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