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Diss Factsheets
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EC number: 203-862-8 | CAS number: 111-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation limited, no range finding for the induction, no information on control animals, several deviations from current guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- according Magnusson and Kligman; Number of animals: 15 test guinea pigs; no data on control guinea pigs;
removal of hair is by shaving Induction: Intradermal Injections In an area of 30 cm² 10 injections (0.05 ml
of a mixture of 0.5 ml test substance and 10 ml Freunds Complete Adjuvans) were placed during 2 weeks.
After the last injection the animals were without treatment for 14 days (no further information available).
Challenge: Topical Application The animals were treated with 0,5 ml of a 0.1% solution which was applied
on a patch under occlusive condition (no further information available) - GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- IUCLID4 Test substance: other TS: n-butyl isocyanate, no data on purity
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright-Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: no data for the main study available
- Concentration / amount:
- induction: 0.05 ml of a mixture of 0.5 ml test substance and 10 ml Freunds adjuvant
challenge: 0.5 ml of a 0.1% solution
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: no data for the main study available
- Concentration / amount:
- induction: 0.05 ml of a mixture of 0.5 ml test substance and 10 ml Freunds adjuvant
challenge: 0.5 ml of a 0.1% solution
- No. of animals per dose:
- 15
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 0.5
- Group:
- test chemical
- Dose level:
- 0.5 ml
- No. with + reactions:
- 15
- Total no. in group:
- 15
- Clinical observations:
- 30 minutes after application the site of injection were strongly reddened with blue red discoloration after 5-6 hours.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 0.5. Group: test group. Dose level: 0.5 ml. No with. + reactions: 15.0. Total no. in groups: 15.0. Clinical observations: 30 minutes after application the site of injection were strongly reddened with blue red discoloration after 5-6 hours..
Any other information on results incl. tables
REMARK:
Induction:
Immediately after the injection the animals had severe
itching. 30 minutes after application the site of injection
were strongly reddened with blue red discoloration after
5-6 hours. During the treatment-period of 14 days a distinct
exacerbation was observed. During the resting period partly
healing of the wounds with eschar formation occurred
Challenge:
0.1%: 15/15 (no data on control animals available) with
distinct, up to strong erythema on the treated flanks with
slight edema in several animals. Some animals showed
itching. After 48 hours the treated skin of all animals was
slightly reddened; after 72 hours all effects were
reversible to a large extent (no further information
available)
RESULT:
Number of animals: 15 test guinea pigs; no data on control
guinea pigs; removal of hair is by shaving
Induction: Intradermal Injections
In an area of 30 cm² 10 injections (0.05 ml of a mixture of
0.5 ml test substance and 10 ml Freunds Complete Adjuvans)
were placed during 2 weeks. After the last injection the
animals were without treatment for 14 days (no further
information available).
Challenge: Topical Application
The animals were treated with 0,5 ml of a 0.1% solution
which was applied on a patch under occlusive condition (no
further information available)
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Executive summary:
according Magnusson and Kligman; Number of animals: 15 test guinea pigs; no data on control guinea pigs;
removal of hair is by shaving Induction: Intradermal Injections In an area of 30 cm² 10 injections (0.05 ml
of a mixture of 0.5 ml test substance and 10 ml Freunds Complete Adjuvans) were placed during 2 weeks.
After the last injection the animals were without treatment for 14 days (no further information available).
Challenge: Topical Application The animals were treated with 0,5 ml of a 0.1% solution which was applied
on a patch under occlusive condition (no further information available)
RESULT: substance is sensitising
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