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EC number: 251-974-0 | CAS number: 34375-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Prediction done using Bioconcentration factor (v12.1.0.50374).This particular module provides bioconcentration factor (BCF) values over the entire pH scale. Calculations are performed for both neutral and ionic species present at a given pH and utilize predicted values for LogP as well as pKa. The BCF and Koc values characterize the tendency for a compound to accumulate in aquatic organisms and soil respectively, putting these two values among the most important ones in the assessment of environmental fate of chemicals.
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-(hydroxymethylamino)ethanol
- Molecular formula (if other than submission substance): C3H9NO2
- Molecular weight (if other than submission substance): 91.1091 g/mol
- Smiles notation (if other than submission substance): CN(CCO)O
- InChl (if other than submission substance): 1S/C3H9NO2/c1-4(6)2-3-5/h5-6H,2-3H2,1H3
- Substance type: Organic
- Physical state: Liquid - Radiolabelling:
- no
- Vehicle:
- not specified
- Test organisms (species):
- other: aquatic organisms
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Reference substance (positive control):
- not specified
- Type:
- BCF
- Value:
- 1 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: no data
- Remarks on result:
- other: BCF reported at pH range 1-14
- Validity criteria fulfilled:
- not specified
- Conclusions:
- From Scifinder, Chemspider database and Using Bio-concentration Factor (v12.1.0.50374) module of ACD lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).
- Executive summary:
From Scifinder,Chemspider database and Using Bio-concentration Factor (v12.1.0.50374) module of ACD lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).This value indicates that the test substance 2-[hydroxy(methyl)amino]ethanol found to be non-accumulative in aquatic organisms.
Reference
Description of key information
From Scifinder,Chemspider database and Using Bio-concentration Factor (v12.1.0.50374) module of ACD lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).This value indicates that the test substance 2-[hydroxy(methyl)amino]ethanol was likely to be non-accumulative in aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 1 dimensionless
Additional information
Three results including different predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) were summarized as follows:
First prediction done using ACD (Advanced Chemistry Development)/I-Lab; Algorithm Version: v5.0.0.184 using Bio-concentration Factor (v12.1.0.50374) module and also from Scifinder and chemspider database; 2017 indicate the bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).This value indicates that the test substance 2-[hydroxy(methyl)amino]ethanol found to be non-accumulative in aquatic organisms.
Another validated prediction by BCFBAF (v3.00) model and PBT profiler database indicate the estimated bio concentration factor (BCF) for 2-[hydroxy(methyl)amino]ethanol is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 2-[hydroxy(methyl)amino]ethanol is not expected to bio accumulate in the aquatic environment.
Above all predictions assist by result from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) indicate the bioaccumulation i.e BCF for test substance 2-[hydroxy(methyl)amino]ethanol was estimated to be 3.14 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 2-[hydroxy(methyl)amino]ethanol non-bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Thus based on the above information for bioaccumulation endpoint, it can be concluded that the test substance 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) is expected to be non Bioaccumulative in aquatic environment as none of the study indicate the 2-[hydroxy(methyl)amino]ethanol exceed the BCF threshold of 2000.
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