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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of Some Perhalogenated Acetones
- Author:
- Joseph F. Borzelleca, David Lester
- Year:
- 1 965
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 7, 592-597 (1965)
Materials and methods
- Principles of method if other than guideline:
- Adult, male, albino rabbits,averaging 2 kg in weight, were used, usually 10 al each of 3 or 4 dosagee of a compound. The hair from the trunk of the
animal was removed by means of an electric dipper. A rubber girdle was fitted, and the rabbit was placed in an individual restraining stock
(Draize et al., 1944) for the 24-hour exposure period. The test liquid was then injected under the girdle and permitted to remain in contact with the
skin for 24 hours. At the end of the contact period, the girdles were removed, the skin was wiped dry, and the rabbits were examined and returned to individual cages. They were maintained under observation at 23 ± 1 °c for 4-6 weeks, during which they were fed a commercial chow.
The LD50 values were calculated by the minimum approximate chi-square normit method of Berkson (1955). - GLP compliance:
- not specified
- Test type:
- other: min. 3 dose groups
- Limit test:
- no
Test material
- Reference substance name:
- Hexachloroacetone
- EC Number:
- 204-129-5
- EC Name:
- Hexachloroacetone
- Cas Number:
- 116-16-5
- Molecular formula:
- C3Cl6O
- IUPAC Name:
- hexachloropropan-2-one
- Details on test material:
- Boiling point: 204 °C
Specific gravity: 1.73 (25°C)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Adult, male, albino rabbits,averaging 2 kg in weight, were used, usually 10 al each of 3 or 4 dosagee of a compound.
The hair from the trunk of the animal was removed by means of an electric clipper.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The hair from the trunk of the
animal was removed by means of an electric dipper. A rubber girdle was fitted, and the rabbit was placed in an individual restraining stock
(Draize et al., 1944) for the 24-hour exposure period. The test liquid was then injected under the girdle and permitted to remain in contact with
the skin for 24 hours. At the end of the contact period, the girdles were removed, the skin was wiped dry, and the rabbits were examined and
returned to individual cages. They were maintained under observation at 23 ± 1 °c for 4-6 weeks, during which they were fed a commercial chow. - Duration of exposure:
- 24h
- Doses:
- no data
- No. of animals per sex per dose:
- 10 at each of 3 or 4 dosages of a compound
- Control animals:
- not required
- Details on study design:
- A rubber girdle was fitted, and the rabbit was placed in an individual restraining stock (Draize et al., 1944) for the 24-hour exposure period. The test liquid was then injected under the girdle and permitted to remain in contact with the skin for 24 hours. At the end of the contact period, the girdles
were removed, the skin was wiped dry, and the rabbits were examined and returned to individual cages. They were maintained under observation at 23 ± 1°C for 4 - 6 weeks, during which they were fed a commercial chow. - Statistics:
- The LD50 values were calculated by the minimum approximate chi-square normit method of Berkson (1955).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 900 - 4 060 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mild central nervous system depression preceded death, but no other abnormal signs were evident.
- Clinical signs:
- other: There was no measurable amount of material remaining under the girdle at the end of the exposure period, The exposed area appeared erythematous and was very clearly delineated from the adjacent unexposed areas. These exposed areas then became scaly or de
- Gross pathology:
- No abnormalities were present on gross autopsy except for tbe discoloration and edema of the exposed skin.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- LD50 = 2980 +/- 1080 mg/kg bw (determined with 30-40 albino rabbits).
- Executive summary:
The acute LD50 of dermal administration is presented. The compound was administrated by dermal application (occlusive, 24 h) to rabbits. The compound caused some depression of the central nervous system, but otherwise, no specific toxic signs were associated with lethal doses. Dermal application did not lead to pulmonary damage from hexachloroaceton.
The mechanism of the lethal action of the latter compounds is not apparent in these studies.In the latter case, the pulmonary absorption is less than half the gastrointestinal absorption. These calculations are interpreted as evidence that the lethal action of these compounds excluding hexachloroacetone is manifested entirely systemically.
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