Registration Dossier
Registration Dossier
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EC number: 203-564-8 | CAS number: 108-24-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV
- Author:
- Smyth H.F. et al.
- Year:
- 1 951
- Bibliographic source:
- Archiv. Industr. Hyg. Occup. Med. 4: 119-122
- Reference Type:
- publication
- Title:
- Acetic acid and its derivatives: key properties and hazards.
- Author:
- Lodal PN
- Year:
- 1 992
- Bibliographic source:
- cited in: Eastman Chemical Company, Kingsport, Tennessee.
- Reference Type:
- secondary source
- Title:
- Acetic Anhydride
- Author:
- OECD SIDS
- Year:
- 1 997
- Bibliographic source:
- SIDS Initial Assessment Report for 6th SIAM (Paris, 9-11 June 1997)
Materials and methods
- Principles of method if other than guideline:
- As described in Smyth, H.F. and Carpenter, C.P. Journal of Industrial Hygiene and Toxicology, 26(8). 269-273, 1944
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- - Name of test material (as cited in study report): acetic anhydride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 9
- Max. score:
- 10
- Reversibility:
- not specified
Any other information on results incl. tables
The test substance was found to cause "chemical burn of the eye" and "eye injury from fluid" following 24 h exposure of the eye of albino rabbits. A score of 9 out of a maximum possible score of 10 after 24 hrs was observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
