Registration Dossier
Registration Dossier
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Body responsible for the test
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Body responsible for the test
- IUPAC Name:
- Body responsible for the test
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: 0.5 g of the test substance moistened with tap water and 2 to 3 drops of TWEEN 80 were applied to the intact skin and covered with a surgical gauze.
- Controls:
- not specified
- Duration of treatment / exposure:
- 4h
- Observation period:
- no data
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: all animals
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- other: all animals
- Score:
- 0
- Reversibility:
- no data
Any other information on results incl. tables
The 'Time points' at which the irritation parameters were determined cannot be provided because the NONS file (provided by ECHA) doesn`t contain this information
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The value of the scores for reythema and odema was 0 in all animals. The substance is not classified as irritating to the skin.
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