Registration Dossier
Registration Dossier
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EC number: 910-245-3 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure according to national standards; report with limited detail.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- SOURCE: AKZO N.V.
PURITY: Not reported
IMPURITY/ADDITIVE/ETC.: Not reported
ANY OTHER INFORMATION: The test substance Natron Waterglass 40/42 (ratio 2.0) is a clear colourless liquid. Density was 1.39. Concentration not indicated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cpb:Wu; Wistar random
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Strain: Not reported
- Source: The Central Institute for the Breeding of Laboratory Animals TNO, Zeist, Netherlands
- Age: Young adult
- Weight at study initiation: 196-336 g (males), 142-195 (females)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- - Volume administered: 2.50, 3.00, 3.60, 4.32, 5.20 mL/kg
- Doses:
- 3.30, 3.96, 4.75, 5.70, 6.86 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Post dose observation: 14 days after treatment
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 400 mg/kg bw
Any other information on results incl. tables
MORTALITY:
- Time of death: Between 5 hours and 2 days after dosing
- Number of deaths at each dose:
Dose male female
3.30 0/5 1/5
3.96 0/5 2/5
4.75 1/5 1/5
5.70 2/5 1/5
6.86 5/5 5/5
CLINICAL SIGNS: Sedation, abdominal discomfort, sluggishness
and unconsciousness
NECROPSY FINDINGS: No treatment related gross alterations
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
