Benzyl propionate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Article in foreign language (Japanese). Basic information obtained from the english translated summary and tables.

Data source

Reference

Reference Type:

publication

Title:

Studies on Compoxinded Perfumes for Toilet Goods. On the Non-irritative Compounded Perfumes for Soaps

Author:

Tetsuya Fujii , Saburö Furukawa and Seiji Suzuki

Year:

1972

Bibliographic source:

Yukugaku 21(12), 904-908

Materials and methods

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Two different closed patch test were conducted on healthy male and female subjects. For the first closed patch test, the small of back of 34 subjects were treated with 20% test substance in vaselinum aldum or unguentum hydrophilicum for 48 hours. In the second closed patch test, 2% test substance was applied on the upper inside of arm of 30 subjects for 24-72 hours. Unguentum simplex and unguentum hydrophilicum served as vehicle.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl propionate

EC Number:

204-559-3

EC Name:

Benzyl propionate

Cas Number:

122-63-4

Molecular formula:

C10H12O2

IUPAC Name:

benzyl propanoate

Method

Ethical approval:

not specified

Details on study design:

- 34 humans (first test) and 30 humans (second test)
- SCORING SYSTEM:
Reactions were recorded according to the following criteria: (-) = No reaction [negative reaction]; (+/- ) = Slight Erythema [suspected positive reaction]; (+) = Erythema [positive reaction]; (++) = Erythema and Dropsical swelling [positive reaction]; (+++) = Erythema, Papules and Vesicles [positive reaction].

Details on exposure:

TYPE OF EXPOSURE: closed

EXPOSURE LEVELS: 20% or 2%

EXPOSURE PERIOD: 24-72 hours (first test), 48 hours (second test)

Results and discussion

Results:

No reactions (erythema) were observed at 20% and 2% of the test substance.

Applicant's summary and conclusion

Conclusions:

No irritant reactions were produced neither at concentration of 20% test substance nor at a dose of 2% test substance.

Executive summary:

The publication described two closed patch tests which were conducted on healthy male and female subjects. For the 48 hour closed patch test, 34 subjects were treated with 20% test substance in vaselinum aldum or unguentum hydrophilicum on the small back. In addition, a 24- to 72 -hour closed patch test was conducted on 30 male and female subjects, with the test item at 2% in unguentum simplex or unguentum hydrophilicum. In both tests, no irritant reactions were produced in the subjects.