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Diss Factsheets
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EC number: 942-932-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no observation period of 14 days, no subdivision of the scores after 72 hours
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-[(2-hydroperoxy-4-methylpentan-2-yl)peroxy]-4-methylpentane-2-peroxol; 4-methylpentan-2-one; 4-methylpentane-2,2-diperoxol
- EC Number:
- 942-932-9
- Cas Number:
- 37206-20-5
- Molecular formula:
- Reaction mass of C6H14O4 and C12H26O6 and C6H12O
- IUPAC Name:
- 2-[(2-hydroperoxy-4-methylpentan-2-yl)peroxy]-4-methylpentane-2-peroxol; 4-methylpentan-2-one; 4-methylpentane-2,2-diperoxol
- Reference substance name:
- Diisobutyl phthalate
- EC Number:
- 201-553-2
- EC Name:
- Diisobutyl phthalate
- Cas Number:
- 84-69-5
- Molecular formula:
- C16H22O4
- IUPAC Name:
- diisobutyl phthalate
- Test material form:
- liquid
Constituent 1
additive 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 12 animals
6 animals intact skin
6 animals abraded skin - Details on study design:
- TEST SITE
- Area of exposure: 1 inch x 1 inch
- Type of wrap if used: The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours
SCORING SYSTEM: By the method of Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal: 1-6
- Time point:
- 24/48/72 h
- Remarks on result:
- other: an overall irritation score is provided only
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-6
- Time point:
- 24/48/72 h
- Remarks on result:
- other: an overall irritation score is provided only
- Irritant / corrosive response data:
- After 24 hours, ischemia and slight to severe edema; after 72 hours, distinct or severe incrustation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The skin irritation potential of the test substance was determined in a study equivalent to OECD guideline 404. The test item showed corrosive effects.
- Executive summary:
The skin irritation potential of the test item was determined in a study equivalent to OECD guideline 404. The test substance was applied undiluted in an amount of 0.5 mL. Six rabbits are treated on the intact skin, the other six on the abraded skin. The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. After an exposure period of 24 hours the patches were removed. The resulting skin reaction were read immediately after 24 hours and after 72 hours. The following scores are indicated as overall mean irritation scores after 72 hours. No subdivision was done for the scores after 72 hours:
Intact skin
Animal 1: 3
Animal 2: 3
Animal 3: 3
Animal 4: 3
Animal 5: 3
Animal 6: 4
Abraded skin
Animal 1: 3
Animal 2: 3
Animal 3: 4
Animal 4: 4
Animal 5: 4
Animal 6: 3
The test item showed skin corrosive effects. The effects were not reversibel after 72 h. After 24 hours, ischemia and slight to severe edema; after 72 hours, distinct or severe incrustation were observed.
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