Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-622-3 | CAS number: 485-71-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Stability:
Data on the stability of cinchonidine are only available for phototransformation. The calculated phototransformation of cinchonidine in air, calculated from the hydroxyl radical turn over rate is 126.3473 E-012 cm^3/molecule/s (1.09 E-05 cm^3/molecule/d). Therefore, we consider phototransformation in air to be negligible. These results are calculated using AOP v1.92, expecting, that phototransformation appears at a constant rate. The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Biodegradation:
The read-across substance cinchonidine hydrochloride was tested in a CO2 Evolution Test according to the OECD Guideline 301 B for 28 days (and 29 days after acidification) to determine whether the test substance is readily biodegradable. On day 28 (after acidification) the degradation in the test vessels reached an extent of 81.2% (mean value of three replicates). There was a high variation in the degradation behaviour due to the difference in the lag phases in the replicate vessels with cinchonidine hydrochloride. Because of the differing lag phases the 10-d-window was evaluated separately. In vessel 15 the lag phase ended between day 4 and 7, in vessel 16 the lag phase ended between day 11 and 14 while in vessel 17 the lag ended between day 11 and day 14. The 10-d-window was reached in all three test vessels. In vessel 15 the degradation extent was already on day 11 above 60%. In vessel 16 and 17 the degradation extent on day 11 was still below 10% and on day 21 it was above 60%. Therefore, cinchonidine hydrochloride reached the pass level for ready biodegradability (60% ThCO2 within a 10-d window). In conclusion, cinchonidine can be considered as readily biodegradable.
Bioaccumulation:
The given BCF, BAF and Biotransformation half-life estimations from the models for cinchonidine show, that cinchonidine has a low accumulation potential. Nevertheless, the EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. However, empirical studies have not been done, so that we consider a BCF of 18.7 L/kg, BAF of 28.1 L/kg and biotransformation half-life of 0.119 days.
Transport and distribution:
The EPI Suite v.4.11. results show that, cinchonidine adsorbs to carbon and in the environment. The major amount is distributed to soil. The estimated Henrys law constant of cinchonidine is approx. 1.47E-009 Pa-m3/mole.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.