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Diss Factsheets
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EC number: 208-952-0 | CAS number: 548-61-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin irritation: none
eye irritation: slight
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test procedure meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- According to ETAD-Subkomitee für Toxikologie 'Empfohlene Methoden zur toxikologischen Untersuchung von Farbstoffen und Hilfsmitteln'.
Treatment of 3 rabbits on the inner side of the ear for 24 hours under occlusive conditions. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg - Duration of treatment / exposure:
- 24 h
- Observation period:
- directly after treatment and 48h thereafter
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: inner side of the ear
- Type of wrap if used: no details given - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0h and 48h
- Score:
- 0
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
In a skin irritation study the test material was applied to the inner side of the ear of 3 white rabbits under occlusive conditions. No signs of skin irritation became obvious directly after treatment and 48 hours thereafter. Thus, the test material did not cause skin irritation under the protocol used. According to EU Regulation 1272/2008 no classification for skin irritation is warranted.
Reference
No skin reaction was observed.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test procedure meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- According to ETAD-Subkomitee für Toxikologie 'Empfohlene Methoden zur toxikologischen Untersuchung von Farbstoffen und Hilfsmitteln'.
The test substance was instilled in one eye of each of 3 rabbits. Observation period was 7 days. - GLP compliance:
- no
- Species:
- rabbit
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the second eye of each rabbit served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg - Observation period (in vivo):
- 1 h, 24 h, 48 h, 72 h and 7 days after treatment
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: mean of 24, 48, and 72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: 1 h after treatment score 1 for erythema
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: 1 h after treatment score 1 for erythema and edema
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: mean of 24, 48, and 72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: 1 h after treatment score 2 for erythema and score 1 for edema
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Instillation of the test substance into one eye of each of three rabbits led to slight erythema in two animals. All effects were fully reversible within the observation time of 7 days. Thus, under the conditions of this test the test substance was slightly irritating to the eyes of rabbits. According to EU Regulation 1272/2008 no classification for eye irritation is warranted.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
In a skin irritation study the test material was applied to the inner side of the ear of 3 white rabbits under occlusive conditions. No signs of skin irritation became obvious directly after treatment and 48 hours thereafter. Thus, the test material did not cause skin irritation under the protocol used. According to EU Regulation 1272/2008 no classification for skin irritation is warranted.
Instillation of the test substance into one eye of each of three rabbits led to slight erythema in two animals. All effects were fully reversible within the observation time of 7 days. Thus, under the conditions of this test the test substance was slightly irritating to the eyes of rabbits. According to EU Regulation 1272/2008 no classification for eye irritation is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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