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EC number: 253-425-0 | CAS number: 37247-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Calcium (when administered orally in feed as Ca-lactate) is not carcinogenic.
Magnesium (when administered orally in feed as Mg-chloride) is not carcinogenic.
The NOAEL of burnt dolomitic lime, converted from Ca taking into account the respective molecular weights, has been determined at 672 mg/kg bw/d.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 672 mg/kg bw/day
Justification for classification or non-classification
No increased rate of tumour formation was observed in studies on calcium lactate in rats and magnesium chloride in mice, respectively. Neither calcium nor magnesium nor calcium magnesium oxide is considered to be carcinogenic. Classification for carcinogenicity is not warranted.
Additional information
There was no evidence of relevant carcinogenic activity of calcium in both sexes of rats receiving 2.5 or 5 % calcium lactate via drinking water for 104 weeks.The NOAEL for tumour formation in this study is represented by the high dose of 5 %, corresponding to calcium lactate pentahydrate doses of 2150 and 2280 mg/kg bw/d to male and female rats, respectively. This is equivalent to calcium doses of approximately 279.5 and 296.4 mg Ca/kg bw/d for male and female rats. Accordingly, the lower NOAEL value of 279.5 mg Ca/kg bw/d (male rats) is established as a NOAEL for carcinogenicity hazard assessment.
A human clinical study (Baron, 1999; technical dossier section 7.10.1) suggests a beneficial effect of calcium supplementation on cancer risk: Calcium supplementation is associated with a significant - though moderate - reduction of the risk of recurrent colorectal adenomas.
Diets containing 2 % MgCl2*6 H2O did not cause carcinogenic effects in B6C3F1 mice of both sex. The NOAELs for tumor formation were 2810 and 3930 mg/kg bw/d for males and females, respectively. These values correspond to doses of 336 and 470 mg Mg/kg bw/d for males and females, respectively.
Accordingly the lower NOAEL value of 336 mg Mg/kg bw/d for male mice, is established as the NOAEL for carcinogenicity hazard assessment.
Both NOAELs (Ca and Mg) are used as a basis for deriving an NOAEL for calcium magnesium oxide.
Considering the molecular weight of magnesium (24.305 g/mol), calcium (40.078 g/mol) and CaMgO2 (96.382 g/mol), this NOAEL can be converted into a NOAEL for calcium magnesium oxide of 672 mg/kg bw/d with respect to calcium and 1332 mg/kg bw/d with respect to magnesium.
Furthermore, epidemiological data on cement workers (cement used as a surrogate for lime; Vestbo, 1991, technical dossier section 7.10.1) indicate no increased overall cancer risk due to inhalation of cement dust in this population.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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