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Diss Factsheets
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EC number: 200-858-8 | CAS number: 75-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance exhibited little or no degradation when tested for ready biodegradability according to OECD 301 D, and exerted an inhibitory effect in the toxicity control. Further studies may be needed to evaluate its biodegradability.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Ready biodegradability was tested according to the Closed Bottle test (OECD 301 D, EC C.4-E) and in compliance with GLP (IBR Forschungs GmbH for RWE-DEA Ag.). The test was performed with a nominal initial test substance concentration of 2 mg/L and inoculum from the domestic sewage treatment plant at Kläranlage Gümmerwald (Hannover, Germany), which was collected freshly on day 0 of the test and filtered through a paper filter. The test substance exhibited little or no degradation during the study, and exerted an inhibitory effect in the toxicity control. The reported results for the biodegradation of the sodium benzoate reference substance fell short of the OECD 301 D validation criterion of at least 60% in 14 days. However, a review of the author’s calculations showed that the value of m0used for all of them was the mean day 0 value from the un-inoculated controls (10.0 mg/L). In comparison, the mean day 0 values for the inoculated blank, the reference substance and the test substance were 9.2, 9.8 and 8.8 mg/L, respectively. OECD 301 D directs that the day 0 value used should be that of the inoculated blank, except where this is different from the day 0 values of the test substance, when each calculation should use its own day 0 value. Recalculation of the biodegradation values in this way makes a marked difference to the results as follows:
|
Isopropyl chloride |
Sodium benzoate |
||
|
Reported |
Recalculated |
Reported |
Recalculated |
5 days |
-5.5% |
-16% |
54% |
72% |
15 days |
2.7% |
-8.2% |
57% |
75% |
28 days |
14% |
2.7% |
75% |
93% |
The recalculated % biodegradation of the reference substance meets the validation criterion of at least 60% in 14 days. The overall outcome of the study remains unchanged in that, under the conditions of the test, the substance was not readily biodegradable and exerted an inhibitory effect on the inoculum. It remains possible that a repeat test using a lower initial test substance concentration and/or a higher concentration of inoculum might show biodegradability.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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