Prop-2-yn-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 402.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Acute toxicity and Skin corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions

Author:

Vernot EH, MacEwen JD, Haun CC & Kinkead ER

Year:

1977

Bibliographic source:

Toxicol. Appl. Pharmacol. 42, 417 - 423

Reference 2

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC & Striegel, JA

Year:

1962

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 23, 95 - 107

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

, 3 animals are used (Study was performed prior to OECD GL 402)

GLP compliance:

no

Remarks:

test predated GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Prop-2-yn-1-ol

EC Number:

203-471-2

EC Name:

Prop-2-yn-1-ol

Cas Number:

107-19-7

Molecular formula:

C3H4O

IUPAC Name:

prop-2-yn-1-ol

Details on test material:

No data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

female

Details on test animals or test system and environmental conditions:

Initial body weight of rabbits: 3-4 kg, Diet: ad libidum, Purina Rabbit Chow.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervoius plastic film. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14-day observation period (Smyth et al., 1962).

Duration of exposure:

24 hr

Doses:

Not indicated

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

Duration of observation period following administration: 14 days

The method used for skin absorption toxicity was essentially that of Smyth et al. (1962), except that three female albino New Zealand rabbits (3 - 4 kg) were used per dose and the doses were kept in place by 8-ply gauze patches under a latex rubber film (method: 24-hour occlusive application). The rabbits were maintained on Purina Rabbit Chow.

Smyth HF, Carpenter CP, Weil CS, Pozzani UC & Striegel, JA (1962). Range-Finding Toxicity Data: List VI, Am. Ind. Hyg. Assoc. J. 23, 95 - 107

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

88 mg/kg bw

Mortality:

Mortality is only given as LD50

Clinical signs:

other: No data

Gross pathology:

No data

Other findings:

No data

Applicant's summary and conclusion

Executive summary:

In an acute dermal toxicity study one group of New Zealand rabbits (3 females) was dermally exposed to Propargyl alcohol for 24 hours. Animals then were observed for one day. The dermal LD50 was estimated as 88 mg/kg bw.