Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- other: handbook or collection of data
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.61
- Temp.:
- 19.8 °C
- pH:
- >= 4 - <= 9
- Remarks on result:
- other: no evident variations at different pHs, so average value used
- Details on results:
- Tested using different pH buffers, with following results:
Log Pow= -2.36 at pH 4, -2.78 at pH 7, -2.68 at pH 9. No evident variation with pH, so average value used. - Conclusions:
- The log Kow of maleic anhydride (as maleic acid) is –2.61.
- Executive summary:
In a GLP guideline study according to OECD 107, the partition coefficient of maleic anhydridewas investigated. As maleic acid hydrolyses rapidly in water, the partition coefficient of maleic anhydride has been determined via its hydrolisation product – maleic acid.
The log Kow of maleic anhydride (as maleic acid) at 19.8 °C is –2.61.
Reference
Description of key information
In a GLP guideline study according to OECD 107, the partition coefficient of maleic anhydride was investigated. As maleic acid hydrolyses rapidly in water, the partition coefficient of maleic anhydride has been determined via its hydrolisation product – maleic acid.
The log Kow of maleic anhydride (as maleic acid) at 19.8 °C is –2.61.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.61
- at the temperature of:
- 20 °C
Additional information
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