Registration Dossier
Registration Dossier
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EC number: 474-260-2 | CAS number: 22841-92-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- Siehe Bemerkungen.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Details on test material:
- Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
MMAD: 3,5 µm - 3,6 µm in der 0,13 mg/L Kammer
4,1 µm - 4,3 µm in der 0,48 mg/L Kammer
4,6 µm - 4,7 µm in der 2,8 mg/L Kammer
Constituent 1
Test animals
- Species:
- other: rat, Crl:CD(SD)
Administration / exposure
- Vehicle:
- other: kein Vehikel
- Details on inhalation exposure:
- Nase
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.44 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 2.8 mg/L; Number of animals: 5; Number of deaths: 0
Female: .13 mg/L; Number of animals: 10; Number of deaths: 0
Female: .48 mg/L; Number of animals: 10; Number of deaths: 6
Female: 2.8 mg/L; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: Todesfälle traten bei den weiblichen Ratten bei 0,48 mg/L und 2,8 mg/L auf. In der 2,8 mg/L-Gruppe starben alle 5 Weibchen während oder kurz nach der Exposition. Bei den männlichen Ratten starb kein Tier.
- Gross pathology:
- Effects on organs:
Hautflecken wurden an den 5 gestorbenen Weibchen der
2,8 mg/L-Gruppe beobachtet. Eine Adhäsion der Leber wurde
bei einem Männchen festgestellt.
Feuchte Haut und Magengeschwüre wurden an 7 von 10 Tieren
der 0,48 mg/L-Gruppe beobachtet.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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