Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 289-339-5 | CAS number: 87741-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene.
- Author:
- Carpenter, C.P. et al.
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Reference Type:
- review article or handbook
- Title:
- Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents.
- Author:
- Morrissey, R.E. et al.
- Year:
- 1 990
- Bibliographic source:
- Environ Health Persp. 86; 79-84.
- Reference Type:
- publication
- Title:
- Male-mediated F1 effects in mice exposed to 1,3-butadiene.
- Author:
- Anderson, D. et al.
- Year:
- 1 993
- Bibliographic source:
- In: Sorsa et al. (eds). Butadiene and styrene: Assessment of health hazards. IARC Scientific Publications. IARC: Lyon, France. pp 171-181.
- Reference Type:
- publication
- Title:
- Mutagenicity of 1,3-butadiene inhalation in somatic and germinal cells of mice.
- Author:
- Adler, I-D. et al.
- Year:
- 1 994
- Bibliographic source:
- Mutat Res. 309; 307-314.
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
- CAS number: 106-99-0
- EINECS number: 203-450-8
Constituent 1
Test animals
- Species:
- other: rat, guinea pig, rabbit, mouse
Administration / exposure
- Route of administration:
- inhalation: gas
- Details on mating procedure:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3 -Butadiene
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Mice: There was no evidence to indicate an effect of exposure on fertility.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
There are no adequate studies which assess the effect of butadiene on fertility. An early study is available but was poorly reported and used small numbers of animals (Carpenter et al., 1944). Rats, guinea pigs and rabbits were exposed to 0, 600, 2,300 or 6,700 ppm butadiene, 7.5 hours/day, 6 days/weeks for 8 months. In rats, the number of litters per female was reported to be slightly reduced in the exposed groups but because of inadequacies in the study, no conclusions can be drawn from these data. No effect on fertility has been seen in three dominant lethal studies in mice, reported in the section on mutagenicity. In the first of these studies, groups of 20 males were exposed to 0, 200, 1,000 or 5,000 ppm butadiene 6 hours/day for 5 days and then mated with unexposed females (Hackett et al., 1988b, summarised by Morissey et al., 1990). There was an indication from effects seen in the first 2 weeks post-exposure that butadiene may result in damage to the more mature sperm cells, spermatozoa and spermatids. However, the results were not conclusive. Similarly, no evidence for an effect on fertility was seen in a second dominant lethal study in mice, in which animals were exposed to butadiene either as a single exposure or in a repeated exposure regime (Anderson et al., 1993). In the single exposure protocol, groups of 25 male mice were exposed to 0 or 1,250 ppm while 50 male mice were exposed to 6,250 ppm butadiene for 6 hours. Animals were mated with unexposed females 5 days post-exposure. In the repeated exposure method, 25 males were exposed to 0 or 12.5 ppm while 50 mice were exposed to 1,250 ppm butadiene, 6 hours/day, 5 days/week for 10 weeks and then mated immediately with unexposed females. In the third study, conducted in (102/E1xC3H/E1)F1 mice, groups of 20 males were exposed to 0 or 1,300 ppm butadiene 6 hours/day for 5 days (Adler et al., 1994). At 4 hours after the last exposure each male was mated with pairs of unexposed females for a period of 4 weeks. There was no evidence to indicate an effect of exposure on fertility.
Applicant's summary and conclusion
- Conclusions:
- There was no evidence to indicate an effect of exposure on fertility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.