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EC number: 232-051-1 | CAS number: 7784-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity
- Author:
- Varner JA, Jensen KF, Horvath W, & Isaacson RL
- Year:
- 1 998
- Bibliographic source:
- Brain Research; 784: 284-298
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigating alterations in the nervous system resulting from chronic administration (i.e., 52 weeks) of aluminum fluoride.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aluminium fluoride
- EC Number:
- 232-051-1
- EC Name:
- Aluminium fluoride
- Cas Number:
- 7784-18-1
- Molecular formula:
- AlF3
- IUPAC Name:
- aluminum trifluoride
- Details on test material:
- - Name of test material (as cited in study report): Aluminum fluoride
Constituent 1
Results and discussion
Any other information on results incl. tables
- Brain: Al-fluorescence in sections of the brain was exclusively associated with vasculature where it occurred as deposits within the lumen, within endothelial cells, and in the adventitia. Greater amounts of Al-fluorescence were observed to occur in the deeper layers of the neocortex and in the hippocampus of the left hemisphere than in the right. The AlF group exhibited greater fluorescence in layers 5 and 6 of the left hemisphere than the controls. CA3 and CA4 regions of the hippocampus of the left hemisphere of the brains from the AlF3 group also exhibited increased fluorescence compared to controls.
- Kidney: Some Al-fluorescence was detected within glomeruli and tubules; however, substantially more fluorescence was associated with vasculature.
- Liver: Al-fluorescence could be detected in the sinuses and blood vessels of all animals.
- Kidney: Glomerular hypercellularity and mesangial proliferation apparent in animals from the AlF3 treatment groups. A deposition of protein also was noted in the tubules. There was a significant increase in the extent of monocyte infiltration in the animals treated with AlF3 compared to controls.
- Liver: No differences among the groups were observed in the liver. All hepatocytes appeared normal in shape displaying the typical rounded appearance with demonstrable nuclei and chromatin. Sinusoids, venules, and vessels all appeared normal.
- Spleen: While there was some infiltration of the marginal zones of the spleen by reactive lymphocytes in AlF3 -treated rats, no consistent pattern of treatment-related pathological alterations was apparent.
- Neuronal integrity: There were more moderately damaged and grossly abnormal cells in areas CA1 and CA4 of the right hippocampus in the AlF3 group than in the control group. In neocortical layers 2 and 3 of the left hemisphere, the AlF3 group had more abnormal cells than did controls. Corresponding increases in the frequency of normal appearing cells were observed in neocortex of control animals. In the hippocampus, neuronal density was decreased in area CA3 in the left hemisphere of the AlF3 group relative to controls. Additionally, a significant decrease in neuronal density of neocortical layers 2 and 3 was noted in the left hemisphere of AlF3 group relative to the controls. Significant reductions of cell density were found in layers 5 and 6 of the AlF3 group compared to controls in the left hemisphere.
- CerebroÍasculature integrity: In control animals, the localization of IgM was largely restricted to the vascular lumen, indicative of the integrity of the BBB to IgM. Staining of the neuronal parenchyma in the AlF3 group was significantly increased in the right hemisphere. No differences were found among the groups in the IgM immunoreactivity in the left hemisphere.
General condition of the animals: Progressive general decline in appearance of the AlF3 animals noted throughout the experiment. In addition to the yellowing of the hair that occurs with age, the hair of animals in the AlF3 group became sparse revealing the underlying skin which was dry, flaky, and of a copper color. Although the body weights did not differ among the groups, there was a greater number of deaths in the AlF3 group than in the control group.
Aluminum levels in tissue samples: Brains and kidneys of the AlF3 group exhibited elevated Al levels compared to the control group. There was no difference between the groups in Al levels in the liver.
Distribution of aluminum:
Mosphological assessments:
Applicant's summary and conclusion
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