Registration Dossier
Registration Dossier
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EC number: 203-051-9 | CAS number: 102-76-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: review article
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature (from review article with incomplete experimental data)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of triacetin.
- Author:
- Fiume, M.Z.
- Year:
- 2 003
- Bibliographic source:
- Int J Toxicol. 2003;22 Suppl 2:1-10.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- review article with incomplete experimental data
- Principles of method if other than guideline:
- The acute dermal LD50 of Triacetin was determined using groups of five albino rabbits.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triacetin
- EC Number:
- 203-051-9
- EC Name:
- Triacetin
- Cas Number:
- 102-76-1
- Molecular formula:
- C9H14O6
- IUPAC Name:
- 1,3-bis(acetyloxy)propan-2-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): triacetin
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- A dose of 5 g/kg bw was applied to intact and abraded skin.
- Duration of exposure:
- single application
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The animals were observed for 7 days after dosing.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: rabbit
- Mortality:
- None of the animals died.
Any other information on results incl. tables
The dermal LD50 of Triacetin for rabbits was >5 g/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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