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Diss Factsheets
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EC number: 231-853-9 | CAS number: 7761-88-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to state of the art methodology at that time; methods are well described and results are presented reasonable in the text and in tabular format.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of some silver salts on the eye
- Author:
- Calvery, H.O.; et al.
- Year:
- 1 941
- Bibliographic source:
- Arch. Ophthalmol. 25, 839-847
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study on effects of some silver salts on the eye. The following irritation parameters were scored in this old study (1941): hyperemia, swelling, scar tissue formation, mucopurulent exudation, coagulation and corneal injury. These parameters are different from current standardised test protocols. Unfortunately, they cannot be entered in the technical dossier in a way that the CSR plugin provides a meaningful output in the CSR. Thus we merely state that based on this study silver nitrate can classified as highly irritating to eyes. The full study report is attached to the corresponding endpoint record in the technical dossier.
- GLP compliance:
- no
Test material
- Reference substance name:
- Silver nitrate
- EC Number:
- 231-853-9
- EC Name:
- Silver nitrate
- Cas Number:
- 7761-88-8
- Molecular formula:
- AgNO3
- IUPAC Name:
- Silver nitrate
- Details on test material:
- - Name of test material (as cited in study report): silver nitrate
- Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: pure albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: several different sources
- Age at study initiation: young adults (exact ages were not known)
- Weight at study initiation: 1.5 - 3 kg
- Housing: in air-conditioned quarters, individually housing
- Diet: standard diet
No further details are given.
Test system
- Vehicle:
- not specified
- Controls:
- other: the right eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The material was administered by instilling 0.2 - 1.0 drop of the solution into the lower cul-de-sac of the left eye.
- Concentration (if solution): The concentrations of the solutions varied in strength from 1 to 12%, calculated on the basis of silver nitrate.
- Positive controls: One group of animals received distilled water, another 3% boric acid and another an 0.85% saline solution. - Duration of treatment / exposure:
- 2 to 5 minutes
- Observation period (in vivo):
- at least once every 24 hours
- Number of animals or in vitro replicates:
- up to 10 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 2 to 5 minutes after application a lavage of 1% boric acid was used in the eye.
SCORING SYSTEM:
Conditions evaluated as follows
0 = no observed changes
1 = mild changes or small amount
2 = moderate changes or a moderate amount
3 = severe changes or a large amount
4 = intense changes or an enormous amount
Results and discussion
In vivo
Results
- Irritation parameter:
- chemosis score
- Remarks:
- hyperemia, swelling, scar tissue formation, mucopurulent exudation, coagulation and corneal injury
- Basis:
- mean
- Time point:
- other: several days
- Reversibility:
- not specified
- Remarks on result:
- not determinable because of methodological limitations
- Irritant / corrosive response data:
- Study on effects of some silver salts on the eye. The following irritation parameters were scored in this old study (1941): hyperemia, swelling, scar tissue formation, mucopurulent exudation, coagulation and corneal injury. These parameters are different from current standardised test protocols. Unfortunately, they cannot be entered in the technical dossier in a way that the CSR plugin provides a meaningful output in the CSR. Thus we merely state that based on this study silver nitrate can classified as highly irritating to eyes. The full study report is attached to the corresponding endpoint record in the technical dossier.
- Other effects:
- Positive controls: In all of these animals the results were negative or there was mild hyperemia, the distilled water being th greatest offender, indicating that osmotic properties may play some part.
Any other information on results incl. tables
Study on effects of some silver salts on the eye. The following irritation parameters were scored in this old study (1941): hyperemia, swelling, scar tissue formation, mucopurulent exudation, coagulation and corneal injury. These parameters are different from current standardised test protocols. Unfortunately, they cannot be entered in the technical dossier in a way that the CSR plugin provides a meaningful output in the CSR. Thus we merely state that based on this study silver nitrate can classified as highly irritating to eyes. The full study report is attached to the corresponding endpoint record in the technical dossier.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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