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Diss Factsheets
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EC number: 201-083-8 | CAS number: 78-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: laboratory worker exposure
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report presents the experience of workers engaged in animal laboratory studies using tetraethyl orthosilicate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 940
Materials and methods
- Principles of method if other than guideline:
- Workers were exposed to vapours of tetraethyl orthosilicate during the handling and use of the material for laboratory studies in animals.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- Molecular formula:
- C8H20O4Si
- IUPAC Name:
- tetraethyl orthosilicate
Constituent 1
Test animals / tissue source
- Species:
- human
Test system
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- worker exposure to vapours during laboratory studies in animals
- Controls:
- no
- Amount / concentration applied:
- 85, 250, 700, 1200 and 3000 ppm, vapour
animal, and presumed worker, exposure concentrations - Duration of treatment / exposure:
- "brief" exposure, details not specified
- Observation period (in vivo):
- none
- Number of animals or in vitro replicates:
- number workers exposed not specified
- Details on study design:
- Laboratory workers were exposed to tetraethyl orthosilicate vapours at the test concentrations used for guinea pig and rat vapour inhalation studies.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: 3000 ppm, vapour
- Basis:
- other: worker
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- other: extremely irritating to eyes and nose of workers
- Irritation parameter:
- other: 1200 ppm, vapour
- Basis:
- other: worker
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- other: stings eyes and nose of and produces tears in workers
- Irritation parameter:
- other: 700 ppm, vapour
- Basis:
- other: worker
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- other: mildly stings eyes and nose of workers, 700 ppm could be tolerated by workers for approximately 30 minutes
- Irritation parameter:
- other: 250 ppm, vapour
- Basis:
- other: workers
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- other: makes eyes and nose of workers tingle slightly
- Irritation parameter:
- other: 85 ppm, vapour
- Basis:
- other: worker
- Time point:
- other: not specified
- Reversibility:
- not specified
- Remarks on result:
- other: can be detected as odor by workers
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating to the human eye
- Conclusions:
- As the key eye data, workers exposed to tetraethyl orthosilicate vapours during pre-OECD guideline / pre-GLP laboratory animal studies showed irritation of the eyes and nose at concentrations of 250 ppm vapour (ca. 2.1 mg/L) and above. Concentrations of 700 ppm vapour (ca. 6.0 mg/L) could be tolerated by workers for approximately 30 minutes. This human finding is assigned reliability score 2. Compared to their studies in the guinea pig and rat (see 7.2.2.224), the authors concluded that human eyes and nose were more sensitive to tetraethyl orthosilicate vapours.
The eye irritant effects in laboratory workers support the Eye Irritation Cat 2 (H319, Causes serious eye irritation) classification in Annex VI of Regulation (EC) No. 1272/2008. This classification is assessed qualitatively as a "low hazard" for this endpoint following REACH Guidance Part E, Table E.3-1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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